نتایج جستجو برای: migration assay

تعداد نتایج: 355211  

Journal: :Anticancer Research 2021

Background/Aim: Colon cancer is the second deadliest malignancy for human. Its correlation with obesity has led to an increasing number of studies focusing on role adipokines in colon development. Apelin, which belongs family adipokines, affects several pathological processes, including heart diseases, and carcinogenesis. In this study, we examined importance apelin receptor (APJ) during motili...

2015
Zhao-dong Du Li-ting Hu Gui-qiu Zhao Ying Li Zhi-zhong Ma

PURPOSE To determine whether protein tyrosine phosphatase 1B (PTP1B) is expressed in rat retinal pigment epithelium (RPE) cells, to evaluate whether inhibition of PTP1B contributes to initiation of RPE cells into an active state, and to investigate the signaling pathways involved in this process. METHODS Rat retinas were detached by trans-scleral injection of 1.4% sodium hyaluronate into the ...

2018
Biao Hao Yan Xiao Fang Song Xiangshu Long Jing Huang Maobo Tian Shiyan Deng Qiang Wu

The proliferation and migration of vascular smooth muscle cells are significant in the development and progression of atherosclerosis and plaque rupture. Metformin is a widely used antidiabetic drug, which has been reported to inhibit cell growth and migration. The antiproliferative and antimigratory effects of metformin have been attributed to 5' adenosine monophosphate-activated protein kinas...

Journal: :Biochemical and biophysical research communications 2014
Amr A Al-Haidari Ingvar Syk Henrik Thorlacius

BACKGROUND Simvastatin is widely used to lower cholesterol levels in patients with cardiovascular diseases, although accumulating evidence suggests that statins, such as simvastatin, also exert numerous anti-tumoral effects. AIM The aim of this study was to examine the effect of simvastatin on colon cancer cell migration. METHODS Migration assays were performed to evaluate CCL17-induced col...

2017
Yingyu Ma Wei Luo Brittany L. Bunch Rachel N. Pratt Donald L. Trump Candace S. Johnson

Metastasis is the major cause of bladder cancer death. 1,25D3, the active metabolite of vitamin D, has shown anti-metastasis activity in several cancer model systems. However, the role of 1,25D3 in migration and invasion in bladder cancer is unknown. To investigate whether 1,25D3 affects migration and invasion, four human bladder cell lines with different reported invasiveness were selected: lo...

2016
Yuyang Feng Lei Feng Di Yu Jian Zou Zhaohui Huang

BACKGROUND The neuronal guidance molecule Slit2 plays suppressive role in tumorigenesis and progression. We previously showed that Slit2-Robo1 inhibit cell migration in colorectal cancer (CRC). However, little is known about its downstream effectors in CRC. This study tries to identify whether the Slit-Robo Rho GTPase activating protein 1 (srGAP1) could mediate the inhibitory effect of Slit2-Ro...

Journal: :Neoplasma 2021

G protein-coupled receptor 56 (GPR56) belongs to the adhesion subfamily, which plays a role in cell progression and survival. The aim of this study was investigate GPR56 gene line impact its protein expression on prognosis colorectal cancer (CRC) patients. effect tumor proliferation (WST-1 assay), invasion (Transwell migration assay, wound healing colony-forming ability (semisolid agar assay) e...

Journal: :Experimental cell research 2010
Noriyuki Kioka Takuya Ito Hiroshi Yamashita Natsuko Uekawa Tsutomu Umemoto Soh Motoyoshi Hiroshi Imai Kenzo Takahashi Hideto Watanabe Masayasu Yamada Kazumitsu Ueda

In the process of tissue injury and repair, epithelial cells rapidly migrate and form epithelial sheets. Vinexin is a cytoplasmic molecule of the integrin-containing cell adhesion complex localized at focal contacts in vitro. Here, we investigated the roles of vinexin in keratinocyte migration in vitro and wound healing in vivo. Vinexin knockdown using siRNA delayed migration of both HaCaT huma...

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