IMPORTANCE In the coming decades, the population of older adults with type 2 diabetes mellitus is expected to grow substantially. Understanding the clinical course of diabetes in this population is critical for establishing evidence-based clinical practice recommendations, identifying research priorities, allocating resources, and setting health care policies. OBJECTIVE To contrast the rates of...

BACKGROUND Microvascular insufficiency represents a major cause of end-organ failure among diabetics. METHODS AND RESULTS In streptozotocin-induced diabetic mice, we evaluated the potential of human tissue kallikrein (hTK) gene as a sole therapy against peripheral microangiopathy. Local delivery of hTK gene halted the progression of microvascular rarefaction in hindlimb skeletal muscle by inh...

Diabetic vascular complications are the most common cause of mortality and morbidity worldwide, with numbers of affected individuals steadily increasing. Diabetic vascular complications can be divided into two categories: macrovascular andmicrovascular complications. Macrovascular complications include coronary artery diseaseand cerebrovascular disease, while microvascular complications include...

BACKGROUND Little is known about the complication burden in later years among early onset type 2 diabetes mellitus (T2DM). AIM To determine the magnitude of diabetes complications and adequacy of risk factor management and to test the hypothesis that diabetes duration is an important contributing factor to these complications. DESIGN A cross-sectional study of secondary care diabetes popula...

1 School of Public Health, Aarhus University, Denmark 2 Division of Human Nutrition, Wageningen University, The Netherlands 3 University of Sheffield, UK 4 Department of Epidemiology and Public Health, University College London, London, UK 5 Albert Einstein College of Medicine, Rose F. Kennedy Center, USA 6 International Centre for Circulatory Health, National Heart & Lung Institute, Imperial C...

OBJECTIVE Skin autofluorescence is a noninvasive measure of the level of tissue accumulation of advanced glycation end products, representing cumulative glycemic and oxidative stress. Recent studies have already shown a relationship between skin autofluorescence and diabetes complications, as well as the predictive value of skin autofluorescence for total and cardiovascular mortality in type 2 ...

Women with gestational diabetes mellitus are at increased risk for developing diabetes mellitus (DM), mainly type 2 DM, as well as metabolic syndrome. The presence of subsequent pregnancies increases the risk. In addition, pregnancy in patients with type 1 and type 2 DM also elevates the risk of morbidity and mortality for both mothers and offspring. Thus, all women with pre-existing type 1 or ...

Perhaps the strongest argument for early detection of diabetic microvascular complications is the finding that 50% of all patients with type 2 diabetes mellitus already have signs of at least 1 diabetic microvascular or macrovascular complication at the time of diagnosis. Prevention of diabetic nephropathy hinges on monitoring; screening for hypertension, poor glucose control, and microalbuminu...

Type 2 diabetes is associated with an increased risk of endothelial dysfunction and microvascular complications with impaired autoregulation of tissue perfusion. Both microvascular disease and cardiovascular autonomic neuropathy may affect cerebral autoregulation. In the present study, we tested the hypothesis that, in the absence of cardiovascular autonomic neuropathy, cerebral autoregulation ...

Objective To explore the impact on microvascular complications, long-term preservation of residual B-cell function and glycemic control of patients with type 1 diabetes treated with autologous nonmyeloablative hematopoietic stem-cell transplantation (AHST) compared with conventional medical therapy (CT). Research design and methods Cross-sectional data of patients treated with AHST were compa...