Adenosine to inosine (A-to-I) editing consists of an RNA modification where single adenosines along the sequence are converted into inosines. Such a biochemical transformation is catalyzed by enzymes belonging family adenosine deaminases acting on (ADARs) and occurs either co- or post-transcriptionally. The employment powerful, high-throughput detection methods has recently revealed that A-to-I...

MicroRNAs (miRNAs) are known to have complicated functions in aquatic species, but little is about the role of miRNAs mollusk species under environmental stress. In this study, we performed small RNA sequencing characterize differentially expressed different tissues (whole tissues, digestive glands, gills, and gonads) blue mussels ( Mytilus galloprovincialis ) exposed cadmium (Cd). summary, 107 ...

MicroRNAs (miRNAs) are a functional small non-coding RNA and play essential roles in gene regulation indevelopment, differentiation proliferation. In order to investigate the miRNAs function Lewis rat hippocampal development, this study, newborn adult hippocampi were deliberately selected analyze miRNA expression profiles by microarray. Microarray analyses identified 22 differentially expressed...

MicroRNAs (miRNAs) are a group of endogenous noncoding small RNAs characterized by high conservation; furthermore, various studies have shown the capability of miRNAs to impact diseases. For example, a study shows that cell-free miRNAs are stable in bodily fluids, which gives circulating miRNAs the ability to be potential biomarkers for noninvasive diagnosis. Additionally, accumulating studies ...

Abstract Background MicroRNAs (miRNAs) have been discovered as novel modulators of gene expression. These molecules are involved in regulating lipid metabolism through a complicated interactive mechanism involving regulatory networks and can play role metabolic diseases. PCSK9 (proprotein convertase subtilisin/Kexin 9) is critical regulator cholesterol homeostasis. inhibition an effective thera...

BACKGROUND MicroRNAs (miRNAs, miRs) are small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. MicroRNAs are dysregulated in cancer and may play essential roles in tumorigenesis. Additionally, miRNAs have been shown to have prognostic and diagnostic value in certain types of cancer. The objective of this study was to identify dysregulated miRNAs in end...

BACKGROUND MicroRNAs (miRNAs) are small, noncoding RNAs that play an important role in regulating various biological processes through their interaction with cellular messenger RNAs. Extracellular miRNAs in serum, plasma, saliva, and urine have recently been shown to be associated with various pathological conditions including cancer. METHODS With the goal of assessing the distribution of miR...

Alzheimer’s disease (AD) is the leading form of dementia worldwide, but its early detection and diagnosis remain a challenge. MicroRNAs (miRNAs) are group small endogenous RNA molecules that regulate mRNA expression. Recent evidence suggests miRNAs play an important role in five major hallmarks AD pathophysiology: amyloidogenesis, tauopathy, neuroinflammation, synaptic dysfunction, neuronal dea...

In recent years, magnetic nanoparticles (MNPs) have been widely used in many fields due to their advantageous properties, such as biocompatibility, easy modifiability, and high chemical stability. One of these areas is the detection cancer. It essential use existing biomarkers, microRNAs (miRNAs), for early diagnosis this disease. miRNAs are challenging distinguish detect biological samples bec...

Several studies have shown that autopolyploid can tolerate abiotic stresses better than its diploid ancestor. However, the underlying molecular mechanism is poorly known. microRNAs (miRNAs) are small RNAs that regulate the target gene expression post-transcriptionally and play a critical role in the response to abiotic stresses. Duplication of the whole genome can result in the expansion of miR...