Exosomal miRNAs are proposed as excellent candidate biomarkers for clinical applications. However, little is known about their potential roles as prognostic biomarkers in lung cancer. In this study, we explored the prognostic value of plasma exosomal microRNAs (miRNAs) for non-small-cell lung cancer (NSCLC). Using a quantitative polymerase chain reaction (qPCR) array panel, we analyzed 84 plasm...

Aryl hydrocarbon receptor nuclear translocator (ARNT) forms a heterodimer with aryl hydrocarbon receptor or hypoxia inducible factor 1α to mediate biological responses to xenobiotic exposure and hypoxia. Although the regulation mechanism of the ARNT expression is largely unknown, earlier studies reported that the human ARNT protein level was decreased by hydrogen peroxide or reactive oxygen spe...

Exoplanet research is now target rich with a wide diversity of systems making it difficult for high demand observatories to undertake follow up observations over extended periods time. We investigate the effectiveness using 0.4m-class telescopes monitoring transiting hot Jupiters and their host stars. consider two representative case studies: WASP-52b 13 new transits, HAT-P-23b 17 transits conc...

Emerging evidence demonstrates functional contributions of microRNAs (miRNAs) to μ-opioid receptor (MOR) signaling, but the information so far has been mostly limited to their intracellular regulatory mechanisms. The present study aimed to investigate changes in plasma miRNA profiles elicited by opioid treatment in blood samples collected from clinical studies. Healthy male subjects were orally...

miRNAs (miR) are a critical class of small (21–25 nucleotides) noncoding endogenous RNAs implicated in gene expression regulation. We identified miR-23b and miR-27b as miRNAs that are highly upregulated in human breast cancer. We found that engineered knockdown of miR-23b and miR-27b substantially repressed breast cancer growth. Nischarin (NISCH) expression was augmented by knockdown of miR-23b...

Advancements in Case Studies Quantum microRNA Assessment of COVID-19 RNA Vaccine: Hidden Potency BNT162b2 SASR-CoV-2 Spike as MicroRNA Vaccine Fujii YR* Kawada-Cho, 106-6, Atsuta-Ku, Nagoya, Japan *Corresponding author: Yoichi Robertus Fujii, Submission: March 05, 2021;Published: 16, 2021 DOI: 10.31031/AICS.2021.03.000552 ISSN 2639-0531Volume3 Issue1

bladder cancer is the fifth most common cancer with significant morbidity and mortality. recently, numerous studies demonstrated that micrornas are emerging as diagnostic biomarkers for bladder cancer. specific mirna profiles have been identified for several samples from patients with bladder cancer. micrornas are noncoding rna molecules of approximately 23 nucleotides that play important roles...

objective(s): menopause and diabetes obviously increase the risk of cardiovascular disease in women. the aims of the present study were to evaluate the effects of ovariectomy in type 2 diabetes on the histology and expression of mirna-29, mirna-133, igf-1 and bcl-2 genes and bcl-2 protein and caspase 3 activity in the hearts of female rats. materials and methods: forty female wistar rats were d...

results treatments through mirnas can prove to be beneficial due to its small size, easy synthesis, targeted and quick delivery. conclusions further work is needed to be done to make mirna treatments available to large number of people suffering from various bone diseases. context mirnas can regulate the expression of genes by interfering in their mrnas, acting as key regulators of diverse cell...