OBJECTIVES Microencapsulation of drugs into preformed polymers is commonly achieved through solvent evaporation techniques or spray drying. We compared these encapsulation methods in terms of controlled drug release properties of prepared microparticles and investigated the underlying mechanisms responsible for the 'burst release' effect. METHODS Using two different pH-responsive polymers wit...

The evolution of polymer based nanoparticles as a drug delivery carrier via pharmaceutical nano/microencapsulation has greatly promoted the development of nano- and micro-medicine in the past few decades. Poly(lactide-co-glycolide) (PLGA) and chitosan, which are biodegradable and biocompatible polymers, have been approved by both the Food & Drug Administration (FDA) and European Medicine Ag...

An oleaginous fraction obtained from an alcohol extract of the fruit of Pterodon pubescens Benth. (FHPp) was microencapsulated in polymeric systems. These systems were developed using a complex coacervation method and consisted of alginate/medium-molecular-weight chitosan (F1-MC), alginate/ chitosan with greater than 75% deacetylation (F2-MC), and alginate/low-molecular-weight chitosan (F3-MC)....

Diabetes mellitus (diabetes) is suffered by more than 180 million people and is responsible for approximately 2.9 million deaths each year. This mortality rate is expected to increase by 50 % in the next decade. Due to the inconvenience of the traditional treatment of diabetes by subcutaneous administration of insulin injection, various attempts are made in the production, purification, formula...

Microencapsulation of plant-beneficial bacteria for use as biopesticides is a growing area interest in the search alternatives to harmful chemical pesticides. In this study, we assessed microencapsulation Gram-negative, non-spore-forming bacterial strain Collimonas arenae Cal35 novel cross-linked alginate microcapsules (CLAMs) formed by spray-drying, and matrix shell (CLAMshell) particles fluid...

1 In the past few years, considerable advances of basic and application researches have taken place in the field of pharmaceutics. The newly recognized research thrust on nanoand microencapsulation is expected to have a revolutionary impact on the human health. To do this, considerable interest has been devoted towards the design of new drug delivery systems with the aim to specifically target ...

Freestanding protein films are interesting for many applications ranging from microencapsulation to tissue engineering. Here, the authors use interfacial rheology to characterize the adsorption kinetics and the rheology of spider-silk films formed at an oil water interface. The high surface activity of the engineered spider-silk proteins results in a fast formation of highly stable films, which...

There has been considerable interest in the biological functions of astaxanthin and its potential applications in the nutraceutical, cosmetics, food, and feed industries in recent years. However, the unstable structure of astaxanthin considerably limits its application. Therefore, this study reports the encapsulation of astaxanthin in calcium alginate beads using the extrusion method to improve...

The objective of this work is to develop a novel coacervation process to produce microcapsules of polylactide (PLA) to encapsulate thyme oil that will be used in cosmetics. The novelty of this approach consists of dissolving PLA in dimethylformamide (DMF) which is a good solvent for PLA but in addition has high solubility in water. Upon contact with water, the homogeneous solution of PLA in DMF...

The objectives of this work were to develop a new technique for lycopene microencapsulation by spray drying using dehumidified air as drying medium and to determine optimum operating conditions. A two-step optimization procedure was used. The encapsulation variables were selected in accordance with the PlackettBurman experimental design and were further optimized via response surface methodolog...