The surface energies of film coating formulations based on hydroxypropyl methylcellulose and containing microcrystalline cellulose, lactose and Tween 20, respectively, have been assessed. The approach taken allowed the components of the surface energy, in terms of the Lifshitz-van der Waals and the acid-base contributions, to be determined. Spreading coefficients of these coating formulations w...

Microcrystalline cellulose-based hydrogels were made using never-dried MCC (AaltoCellTM) as a raw material for high-pressure mechanical treatment consisting of one to five passes at 700 bars. The effects the on crystalline structure, morphology, geometrical dimensions, and specific surface area well rheological properties manufactured cellulose gel product investigated. results indicated that p...

The carboxymethyl-cellulase and Avicelase activities of Thermoactinomyces sp., strain YX, were produced simultaneously with cell growth. Throughout the growth phase these activities were primarily extracellular, with up to 50% adsorbed to residual cellulosic substrate at any one time. On the other hand, the beta-glucosidase activity was associated with the culture solids throughout the entire f...

Microcrystalline cellulose (MCC) has the advantage of a high specific surface area as compared to that of conventional cellulose fibers. In this study the monomer methacrylamide (MAM) was used to treat MCC by grafting copolymerization. SEM, FTIR, and solid C NMR were used to characterize the morphology and composition of MAM-g-MCC. After the chlorination of MAM-g-MCC with 10% sodium hypochlorit...

straightforward in terms of good manufacturing practice requirements than are wet granulation and dry compaction, the pharmaceutical industry is focusing increasingly on this process. Although coarse microcrystalline cellulose (MCC) grade 12 offers outstanding flow properties, the most commonly used grade for direct compression is the well-known fine grade 102. The reason for this preference is...

Purpose: The objective of this work was to prepare and evaluate fast dissolving tablets of the nutraceutical, freeze dried Aloe vera gel. Methods: Fast dissolving tablets of the nutraceutical, freeze-dried Aloe vera gel, were prepared by dry granulation method. The tablets were evaluated for crushing strength, disintegration time, wetting time, friability, drug content and drug release. A 3 2 f...

In the present work, fast disintegrating tablets of prochlorperazine maleate were designed with a view to enhance patient compliance by direct compression method. In this method mucilage of Plantago ovata and crospovidone were used as superdisintegrants (2-8% w/w) along with microcrystalline cellulose (20-60% w/w) and directly compressible mannitol (Pearlitol SD 200) to enhance mouth feel. The ...

Objective: The present study involved the preparation of Diclofenac sodium extended release hydrophobic matrix tablets formulated from Ethylcellulose polymer following its different grades, Ethocel Standard Premium and Ethocel Standard FP Premium. Methods: The matrix tablets were prepared with wet granulation method. Lubricated blends were characterized for physical properties like loose bulk d...

In the present work, fast dissolving tablets of clonazepam were prepared by direct compression method with a view to enhance patient compliance. Three super-disintegrants, viz., crospovidone, croscarmellose sodium and sodium starch glycolate in different ratios with microcrystalline cellulose (Avicel PH-102) along with directly compressible mannitol (Pearlitol SD 200) to enhance mouth feel. The...

Bifunctional fusion proteins consisting of organophosphate hydrolase (OPH) moieties linked to a Clostridium-derived cellulose-binding domain (CBD) were shown to be highly effective in degrading organophosphate nerve agents, enabling purification and immobilization onto different cellulose materials in essentially a single step. Enzyme kinetics studies were performed for the CBD-OPH fusions usin...