BACKGROUND In East Africa, particularly in Ethiopia, bacterial keratitis is a major cause of blindness. OBJECTIVE The aims of this study were to identify risk factors of bacterial keratitis and the spectrum of bacterial etiologies, and to assess the in-vitro antimicrobial susceptibility of these bacterial isolates at Jimma University Specialized Hospital, Southwest Ethiopia. METHODS A prosp...

PURPOSE To determine the distribution of invasive and cytotoxic genotypes among ocular isolates of P. aeruginosa and investigate the influence of the type III secretion system (T3SS) on adhesion to conventional, cosmetic, and silicone hydrogel contact lenses (CL). METHODS Clinical isolates from 2001 to 2010 were analyzed by multiplex PCR for exoS, exoU, and exoT genes. Bacterial adhesion to e...

Background: To assess the outcome of therapeutic penetrating keratoplasty(PK) in nonresponsive microbial keratitis cases. Material and methods: Clinical outcomes of sixty patients who underwent therapeutic PK by a single surgeon in our Institute between April 2004 and March 2008 were retrospectively analysed from data obtained from Institutional PK registry of medical record section. Outcome pa...

AIMS A case-control study was performed to evaluate soft contact lens (SCL) wear modality as a risk factor for microbial keratitis. METHODS Contact lens wearers presenting as new patients to Moorfields Eye Hospital accident and emergency department during a 12 month period completed a self administered questionnaire detailing demographic data and contact lens use habits. Cases were patients w...

BACKGROUND To determine the relationship between type three secretion genotype and fluoroquinolone resistance for P. aeruginosa strains isolated from microbial keratitis during the Steroids for Corneal Ulcers Trial (SCUT) and for two laboratory strains, PA103 and PAO1. METHODS Confirmed P. aeruginosa isolates from the SCUT were divided into exoU(+) or exoU(-). The exoU(+) strains contained th...