A stability-indicating micellar liquid chromatographic (MLC) method was developed and validated for the quantitative determination of timolol maleate (TM) in the presence of its degradation products resulting from accelerated degradation in a run time not more than 8 min. TM was subjected to stress conditions of hydrolysis (including alkaline, acidic and thermal hydrolysis) and oxidation. An is...

residual lignin of wood after mwl isolation was dissolved with 1-butyl-3-methylimidazolium chloride ionic liquid. chemical structure of isolated mwl from poplar wood (popolus deltiodes) and dissolved residual lignin were characterized with gas chromatography and 1d, 2d nmr techniques. analytical results showed that  popolus deltoides wood has more 4-(3-hydroxy-1-propenyl)-2-methoxy phenol units...

background & aim: according to the increase in diseases such as diabetes and obesity, using of saccharose alternatives for producing of low-calorie and sugar-free alternatives, are taken into consideration of researchers and industrialists. among them, steviosidewith the 300 times more sweetness than saccharose has special place, due to is a natural. the aim of this study is optimizing of stevi...

determination of drug residues in food is of great importance due to their toxicity. long-term exposure with low level of drug residues could be important, especially in children. based on document study, oxytetracycline (otc) is a prophylaxis and treatment agent for great number of diseases and possesses a broad spectrum activity against many pathogenic organisms and can be toxic or cause alle...

this study a novel high performance liquid chromatography for the assay of nystatin in oral and vaginal tablets were optimized and validated using box–behnken experimental design. the method was performed in the isocratic mode on a rp-18 column (30 °c) using a mobile phase consisting of 0.05 m ammonium acetate buffer/ methanol mixture (30:70) and a flow-rate of 1.0 ml/min. the method was valida...

purpose : fluoroquinolones are widely used antibiotic for prophylaxis of intra and postoperative infections in individuals undergoing cataract surgery. this study was designed to assess the penetration of ciprofloxacin into the ocular aqueous humor (topical only versus topical and oral administration). methods : studied population (n=47) consisted of two groups: group one (n=26) and group two (...

in this project, eggshell membrane was used as a solid phase extraction sorbent for extraction of morphine followed by hplc analysis. at first, raw eggshell membrane was used and then, because of low adsorption of morphine on untreated eggshell membrane (

silymarin is a mixture of flavonolignans from the seeds of silybum marianum (l.) gaertner,containing silybinin, isosilybinin, silydianin, silychristin and the dihydroflavonol of taxifolin. flavonolignancomponents are largely responsible for the medical benefits attributed to silymarin. the aim of this researchwas to study the variations in composition and content of flavonolignans of silymarin ...

background: the effective therapeutic dose of pralidoxime methylsulphate for organophosphate (op) poisoning is necessary to be clarified. this study was designed to comparatively assess the blood level of pralidoxime (bpl) and clinical outcomes in op poisoned patients treated with intermittent dosing and patients treated with continuous infusion. methods: this was a prospective, open labelled, ...

background and objectives:drimia maritima (l.) stearn also known as squill is a medicinally important plant that has been used for various ailments such as dropsy, respiratory disorders, jaundice and epilepsy from ancient times. proscillaridin a is identified as one of the most effective compounds in the plant with remarkable pharmacological features including efficacy against congestive heart ...