abstractthe purpose of this investigation was to evaluate the antiproliferative and apoptogenic mechanistic studies of methanol extract of anthocephalus cadamba (meac) on dalton’s lymphoma ascites (dla) cells treated mice. determination of antiproliferative activity was performed by using different dla cells (2×106 cells, i.p.) inoculated mice groups (n=12). groups were treated for 14 consecuti...

The aim of the study was to investigate the inhibitory effects of soybean isoflavones (SI) on testicular cell apoptosis in mice with type-2 diabetes, as well as any possible mechanisms of action. Thirty male C57BL/6J mice were randomly divided into the control, diabetic (model), and treatment (SI) groups (n=10 each). After treatment for 20 weeks, testicular cell apoptosis was detected and evalu...

Abstract Ginsenoside Rc is one of the cardinal bioactive components Panax ginseng. The present study aimed to investigate whether ginsenoside exerted protective effects against acute cold exposure-induced myocardial injury in rats. Forty rats were randomly assigned into four groups: Control, model, 10 mg/kg, and 20 mg/kg groups. Rats intragastrically administrated with (10, mg/kg) or vehicle da...

objective(s): several researchers have reported the relationship between infertility in male and varicocele for so many years but the implication of varicocele in female patients is remains elusive. here, we aim to examine the effects of unilateral varicose ovarian vein on antioxidant capacity and oocyte quality of rat ovary after the experimental creation of varicocele in female rats. material...

Radiotherapy plays an important role in the treatment of hepatocellular carcinoma (HCC). Cyclin G1 is a novel member cyclin family, and it abnormally expressed HCC. In this study we investigated radiotherapy HCC cells. The expression was silenced by transfection G1-siRNA into HepG2 cells Huh7 cells, mRNA protein measured qRT-PCR Western blot analysis. proliferation analyzed using MTT assay, rad...

Abstract: Introduction: Traumatic Brain Injury (TBI) conditions require immediate treatment such as the administration of analgesics and sedation, including remifentanil. TBI will affect levels several inflammatory apoptotic proteins MAC, Bax, Bcl-2. Remifentanil with its high affinity to μ-receptors is thought these has neuroprotective properties prevent secondary brain injury. Objectives: Thi...

BACKGROUND AND PURPOSE Ischemic injury in neurons can be strongly reduced by a preceding sublethal ischemic episode, of which the mechanism is poorly understood. Although changes in the expression of apoptosis-related proteins (Bcl-2, Bcl-xl, and Bax) have been considered to be crucially important in ischemic injury, the roles these proteins play in ischemic preconditioning induced by sublethal...

3,4- Methylenedioxymethamphetamine (MDMA or "Ecstasy") is a psychoactive and hallucinogenic drug of abuse. MDMA has been shown to produce neurotoxicity both in animals and humans. Recently, the vasodilator drugs such as pentoxifylline is one of the new strategies which have been considered as neuroprotector. In this study effect of pentoxifylline on bcl-2 gene expression changes in hippocampus ...