In an attempt to identify potential new agents that are active against HIV-1, a series of novel pyridopyrimidine-5-carbohydrazide derivatives featuring a substituted benzylidene fragment were designed and synthesized based on the general pharmacophore of HIV-1 integrase inhibitors. The cytotoxicity profiles of these compounds showed no significant toxicity to human cells and they exhibited anti...

Monovalent cations, Cs+, and alkylammonium ([NR4]+) salts have traditionally been used to precipitate the anions of boranes, carborane metallocarborane clusters. In contrast, in body living organisms general, divalent cations a special relevance. this work, we isolate for first time cobaltabis(dicarbollide) biocompatible biological importance that can application both biology materials science....

MXenes have been introduced as a high energy and power density electrochemical supercapacitor material owing to their specific capacitance stability. The operating potential window and, in turn, of MXene based symmetric asymmetric supercapacitors can be effectively enhanced by the proper choice aqueous electrolyte. Herein, we investigate behavior vacancy-containing i-MXene (Mo1.33CTz) sulfate e...

We have measured the rotational motion of myosin heads in synthetic thick filaments at 4 degrees C in the time range from 10(-7) to 10(-4) seconds, by measuring transient absorption anisotropy of an eosin probe attached to a reactive sulfhydryl on the myosin head. Under conditions that result in monomeric myosin (500 mM ionic strength), the anisotropy decay is independent of pH in the range fro...

The study focuses on the hydro-geochemistry of Shaune Garang glacier’s meltwater concerning glacial geomorphology. Seventy-nine water samples (53 in 2016 and 26 2017) ablation season were analysed. cations dominant order Ca2+ > Mg2+ Na+ K+, anions HCO3− SO42− Cl− NO3−. result demonstrated that abundant ions, accounting for 41.03 34.84% total ionic budget (TZ). high proportions (Ca2+ + Mg2+) ver...

Freshwater contamination remains a challenging issue for the sustainable management of wetland ecosystems. This study aims to evaluate water quality Jhilmila Lake, Kanchanpur, Nepal by adopting standard test procedures, geochemical indices, and multivariate statistical analysis. The surface samples were collected during postmonsoon season in 2018 assess hydrochemical parameters such as pH, elec...

The binding and conformational properties of the divalent cation site required for H+,K(+)-ATPase catalysis have been explored by using Ca2+ as a substitute for Mg2+. 45Ca2+ binding was measured with either a filtration assay or by passage over Dowex cation exchange columns on ice. In the absence of ATP, Ca2+ was bound in a saturating fashion with a stoichiometry of 0.9 mol of Ca2+ per active s...

Studies aimed at mitigating environmental impacts have received attention in recent years. The use of biochar obtained from the pyrolysis is an alternative for recovery organic materials that usually are directly discarded environment. Biochar has potential to recover nutrients wastewater, and latter case, reuse or recycling as a controlled-release fertilizer could be option. However, adsorptio...

An understanding of the interaction mechanisms between exchangeable cations and layered silicates is of interest from both a basic and an applied point of view. Among 2:1 phyllosilicates, a new family of swelling high-charge synthetic micas has been shown to be potentially useful as decontaminant. However, the location of the interlayer cations, their acidity and the water structure in the inte...

The adsorption of [3H]thymidine-labeled plasmid DNA (pHC314; 2.4 kb) of different conformations to chemically pure sand was studied in a flowthrough microenvironment. The extent of adsorption was affected by the concentration and valency of cations, indicating a charge-dependent process. Bivalent cations (Mg2+, Ca2+) were 100-fold more effective than monovalent cations (Na+, K+, NH4+). Quantita...