Editor—We have recently performed a systematic review assessing the efficacy of metoclopramide 10 mg for the prophylaxis against intraoperative and postoperative nausea and vomiting (IONV and PONV) in women undergoing Caesarean delivery under neuraxial anaesthesia. Shortly after the publication of our review, doubts have been raised regarding the validity of data included in the articles by Fuj...

BACKGROUND Controversies persist regarding the effect of prokinetics for the treatment of functional dyspepsia (FD). This study aimed to assess the comparative efficacy of prokinetic agents for the treatment of FD. METHODS Randomized controlled trials (RCTs) of prokinetics for the treatment of FD were identified from core databases. Symptom response rates were extracted and analyzed using odd...

INTRODUCTION The use of prokinetic agents on post-pyloric placement of spiral nasojejunal tubes is controversial. The aim of the present study was to examine if metoclopramide or domperidone can increase the success rate of post-pyloric placement of spiral nasojejunal tubes. METHODS A multicenter, open-label, randomized, controlled trial was conducted in seven hospitals in China between April...

Background Dopamine D2-like receptors are attenuated in aldosterone producing adenoma, lead to overproduction of aldosterone in affected patients, and thus reported to serve as a potential treatment target for primary aldosteronism. The D2 dopamine receptor agonist bromocriptine has been used clinically for reducing tumor mass of pituitary adenomas of lactotroph origin. The aim of the present s...

introduction: headache is the most common neurologic symptom among referees to the emergency department (ed), while the best treatment has not yet been found. therefore, in the present study pain relief effects of metoclopramide and acetaminophen were compared in patients suffered acute primary headache. methods: this study was a double-blind randomized clinical trial performed in imam khomeini...

Although the incidence of extrapyramidal reactions associated with metoclopramide has been reported to be approximately 0.2%, such reactions are rare in the anesthetic field. Several anesthetic adjuvants, including ondansetron and pregabalin, have also been associated with extrapyramidal side effect. Here, the authors report the case of a 47-year-old patient, previously administered pregabalin ...

A method is described for the simultaneous measurement of flow rate, mean transit time, and volume of the intestine during the transport of fluid through a segment of the small intestine of the dog. Using this method, the effect of metoclopramide on motility of the small bowel was assessed. The drug resulted in a decrease in transit time and volume in the test segment of bowel while the flow ra...

Subtherapeutic tacrolimus trough concentrations were noted in a 52-year-old woman who had undergone liver transplantation. Her tacrolimus dosage was increased from 7 to 28 mg twice/day, and ketoconazole therapy was added; however, her tacrolimus concentration remained undetectable. Metoclopramide 10 mg 4 times/day was begun to control the patient's new-onset nausea and vomiting. Within 48 hours...

PURPOSE Sodium bisulfate is known to affect the stability of octreotide. However, the critical concentration of sodium bisulfate is not known. Therefore, we assessed the critical concentration of sodium bisulfate needed to preserve the stability of octreotide using actual drugs containing sodium bisulfate. METHODS Although morphine and metoclopramide preparations are considered to be compatib...

OBJECTIVE To compare the efficacy and safety of a small dose of propofol with other commonly used antiemetics, droperidol and metoclopramide, for the prevention of postoperative nausea and vomiting in patients undergoing middle ear surgery. DESIGN Prospective, randomized, double-blind study. SETTING University-affiliated teaching hospital. PATIENTS Ninety patients (48 females, 42 males) s...