A synthetic androgen 17-α methyltestosterone (MT) commonly used in the production of mono-sex fry Nile tilapia ( Oreochromis niloticus ) during first 21 days for sex reversal has been considered to suppress immunity thereby reduce survival. Present trial was conducted evaluate whether vitamin C (L-ascorbic acid, AA) supplementation would benefit terms survival, growth, and stress resistance. we...

Gonadotropin-releasing hormone (GnRH) neurons are the central regulators of reproduction. GABAergic transmission plays a critical role in pubertal activation of pulsatile GnRH secretion. Self-administration of excessive doses of anabolic androgenic steroids (AAS) disrupts reproductive function and may have critical repercussions for pubertal onset in adolescent users. Here, we demonstrate that ...

Research And Development Expansion of tilapia farming on a commercial scale was hindered by the limited availability of quality fry realized by researchers. Attempts were made to develop a practical technique of massscale fry production at the Asian Institute of Technology (AIT) in Klong Luang, Pathumthani, Thailand. A series of onstation trials were conducted over a decade, maintaining the Chi...

A gas chromatography method with mass spectrometric detection is described for the determination of Salvinorin A, the main active ingredient of the hallucinogenic mint Salvia divinorum. The method was validated in plasma, urine, saliva and sweat using 17-alpha-methyltestosterone as internal standard. The analytes were extracted from biological matrices with chloroform/isopropanol (9:1, v/v). Ch...

Mineralocorticoid receptor (MR) antagonists, such as spironolactone (SPI) and eplerenone (EPL), are useful for the treatment of hypertension and heart failure. However, the use of these two agents has been limited due to endocrine disturbance (SPI) and poor drug action (EPL). In our search for safer and more effective MR antagonists, we identified SM-368229 as a novel non-steroidal MR antagonis...