Dr. R. Peces, Servicio de Nefrologia, Hospital Covadonga, Celestino Villamil s/n, E-33006 Oviedo (Spain) Dear Sir, Intravenous methylprednisolone is currently used before transplantation as well as for the treatment of acute rejection episodes. Hypersensitivity to methylprednisolone is extremely rare and the reported cases were mostly in atopic or asthmatic patients [1–7]. Among them, only 2 ca...

3. Matsuda K, Shimada A, Yoshida N, et al. Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations. Blood. 2007;109(12):5477-5480. 4. Grand FH, Hidalgo-Curtis CE, Ernst T, et al. Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms. Blood. 2009;113(24):6182-6192. 5. Mat...

Treatment with a high-dose, intravenous bolus of methylprednisolone has been reported in numerous cases of rheumatic diseases. The optimal routes of administration, dosage, dosage interval, and other factors are unknown. This report describes uncontrolled clinical observations with a single dose of 320 mg of intramuscular methylprednisolone acetate in patients with rheumatic disease (12 with rh...

6 Bone RC, Fisher CJ Jr. Clemmer TI Slotman CJ, Metz CA, Methylprednisolone Severe Sepsis Study Group. Early methylprednisolone treatment for septic syndrome and the adult respiratory distress syndrome. Chest 1987; 92:1032-036 7 Hooper RG, Kearl RA. Established ARDS treated with a sustamed course ofadrenocortical steroids. Chest 1990; 97:138-43 8 Suchyta MR. Clemmer T1 Orme JF Jr. Morris AH, El...

The effects of glucocorticoids on the uptake of 8 antibiotics by human polymorphonuclear leukocytes (PMNs), and the subsequent bactericidal activity of PMNs with 5 of the antibiotics, were examined. The experiments demonstrated that a synthetic glucocorticoid, methylprednisolone at a concentration of more than 50 mg/I, inhibited the uptake of clindamycin, erythromycin and josamycin, but didn't ...

OBJECTIVE To demonstrate imaging findings during the follow-up of patients with aneurysmal bone cyst (ABC) of C2 treated with intralesional injection of calcitonin and methylprednisolone. METHOD Three patients with ABC of C2 were treated percutaneously with intralesional injection of calcitonin and methylprednisolone. All the patients were females, with ages varying from 6 to 13 years. All of...