BACKGROUND Liver disorder was associated with alcohol consumption caused by hepatic cellular damages. Opuntia ficus-indica fruit extracts (OFIEs), which contain betalain pigments and polyphenols including flavonoids, have been introduced as reducing hangover symptoms and liver protective activity. OBJECTIVE To evaluate hepatoprotective activity of OFIEs and isolated compounds by high-speed co...

This study investigated endothelium-derived vasodilators and potassium channels involved in the modulation of ropivacaine-induced contraction. In endothelium-intact rat aortae, ropivacaine concentration-response curves were generated in the presence or absence of the following inhibitors: the nonspecific nitric oxide synthase (NOS) inhibitor N (ω) -nitro-L-arginine methyl ester (L-NAME), the ne...

The dependence of the rates of intramolecular electron transfer (ET) of mixed-valence complexes of the type {[Ru3O(OAc)6(CO)(L)]2-BL}-1, where L is the pyridyl ligand and BL is the pyrazine on solvent type and temperature is described. Complexes were reduced chemically to obtain the mixed-valence anions in acetonitrile (CH3CN) and methylene chloride (CH2Cl2). Rate constants for intramolecular E...

The discovery of anticancer agents paradigm has been shifted to natural resources to overcome the toxicity of many synthetic agents at early clinical stages. In the present study, the antimutagenic, anticancer, phytochemistry, and free radical scavenging activities of five extracts of Conyza triloba were investigated. Extracts II (water : methanol), III (methylene chloride), and IV (methylene c...

The current study evaluated the Control of Substances Hazardous to Health (COSHH) Essentials model for short-term task-based exposures and full-shift exposures using measured concentrations of three volatile organic chemicals at a small printing plant. A total of 188 exposure measurements of isopropanol and 187 measurements of acetone were collected and each measurement took approximately 60 mi...

OBJECTIVE To study the mechanism by which poly-L-arginine mediates endothelium-dependent relaxation. METHODS Vascular segments with and without endothelium were suspended in organ chambers filled with control solution maintained at 37 C and bubbled with 95% O2 / 5% CO2. Used drugs: indomethacin, acetycholine, EGTA, glybenclamide, ouabain, poly-L-arginine, methylene blue, N G-nitro-L-arginine,...

Improper treatment and disposal of perchlorate can be an environmental hazard in regions where solid rocket motors are used, tested, or stored. The solubility and mobility of perchlorate lends itself to ground water contamination, and some of these sources are used for drinking water. Perchlorate in drinking water has been determined at sub-mug l(-1) levels by extraction of the ion-pair formed ...

Acute Exposure Guideline Levels (AEGLs) are derived to protect the human population from adverse health effects in case of single exposure due to an accidental release of chemicals into the atmosphere. AEGLs are set at three different levels of increasing toxicity for exposure durations ranging from 10 min to 8 hours. In the AEGL-setting for methylene chloride specific additional topics had to ...

A cyclic hexapeptide, cyclo(Pro-Gly-Pro-Gly-Pro-Gly), has been synthesized; its solution conformations were examined by 220-MHz nuclear magnetic resonance spectroscopy. The solution structures have been deduced, and shown to vary as a function of solvent polarity. In addition, it has been found that this cyclic peptide binds alkali metal cations. While the predominant conformation of this cycli...

OBJECTIVE To identify the antimicrobial components present in Microglossa angolensis following fractionation of the methylene chloride extract of the aerial part of this plant. MATERIALS AND METHODS The plant was dried and extracted by percolation with methylene chloride. The dry extract was fractionated and purified by silica gel column chromatography. The isolated compounds were identified ...