The modulation of cell proliferation in neural progenitor cells (NPCs) is believed to play a role in neuronal regeneration. Recent studies showed that K(+) channel activity influenced cell proliferation. Therefore, we examined NPCs for K(+) channels and tested whether NPC self renewing can be modulated by synthetic K(+) channel modulators. The whole-cell K(+) current was partly K(+) dependent a...

The synthesis of 5-cyanomethoxy-2-thiouracil (5b) is described. The acid catalysed ethanolysis of 5b leads to 5-ethoxycarbonylmethoxy-2-thiouracil (5a). Condensations of 5-methoxy-2thiouracil (5) and 5a with the sugar component 7 using the "silyl method" yield peracylated 5-methoxy-2-thiouridine (8) and 5-ethoxycarbonylmethoxy-2-thiouridine (8a), which under treatment with sodium methanolate/me...

Further studies on the bark of Taiwania cryptomerioides found four new podocarpane derivatives, 1beta,13-dihydroxy-8,11,13-podocarpatriene (1), 14,18-dihydroxy-13-methoxy-8,11,13-podocarpatriene (2), 1beta,14-dihydroxy-13-methoxy-8,11,13-podocarpatriene-2,7-dione (3), and 3beta,14-dihydroxy-13-methoxy-8,11,13-podocarpatrien-7-one (4), together with a known 1beta,13,14-trihydroxy-8,11,13-podocar...

für Naturforschung in cooperation with the Max Planck Society for the Advancement of Science under a Creative Commons Attribution 4.0 International License. Dieses Werk wurde im Jahr 2013 vom Verlag Zeitschrift für Naturforschung in Zusammenarbeit mit der Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. digitalisiert und unter folgender Lizenz veröffentlicht: Creative Commons Namen...

Skimmia laureola Hook (Rutaceae) is found in Kashmir and in the mountains of Northern Pakistan and is used in folklore medicine for the treatment of various ailments [1 – 3]. The quinoline alkaloids of this plant have demonstrated antifungal and immunomodulating properties [4, 5]. The ethanolic extracts of the aerial parts of S. laureola are active against the animal pathogen Microsporium canis...

Umbelliferone, 13 lignans and an unusual compound 2-(3,4-methylenedioxyphenyl)propane-1,3-diol, were isolated from the leaves of Juniperus chinensis. The lignans include meso-secoisolariciresinol, 3,4-methylenedioxy-3’,4’dimethoxylignan-9’,9-olide, hibalactone, isohibalactone, 7-oxohinokinin, 7-hydroxyhinokinin, 7-acetyloxyhinokinin, (+ )-xanthoxylol, dihydrodehydrodiconiferyl alcohol, 3-methox...

From the treatment of 5-hydroxy-1,4-naphthoquinone (juglone) with acetic anhydride and H2SO4 followed subsequently by treatment with methanolic HCl, 5-hydroxy-3-methoxy-1,4-naphthoquinone (3-methoxy juglone) and 8-hydroxy-4-methoxy-1,2-naphthoquinone were obtained as products rather than the anticipated product 2,5-dihydroxy-1,4-naphthoquinone (2-hydroxy juglone). The reaction and the identific...

The title compound, C(29)H(28)O(9), was isolated from the reaction of 4,6-dimeth-oxy-2-(4-methoxy-phen-yl)-3-benzofuran and α-methoxy-carbonyl-cinnaminate. The two aromatic rings form a dihedral angle of 22.7 (1)°. One methoxy-carbonyl group is disordered between two orientations in a 0.612 (4):0.388 (4) ratio. The crystal structure exhibits no significantly short inter-molecular contacts.