Two stability indicating chromatographic methods were proposed for the determination of almotriptan, eletriptan, and rizatriptan, in presence of their acid degradation products. The first method is a quantitative densitometric thin layer chromatography. The developing systems were; acetonitrile: methanol: dichloromethane: ammonia (10:6:3:1 v/v), ethyl acetate: methanol: ammonia (15:4:1 v/v), an...

This study investigated the effects of the methanol extracts of Morinda citrifolia containing numerous anthraquinone and iridoid on phospholipase A(2) (PLA(2)) isozyme. PLA(2) activity was measured using various PLA(2) substrates, including 10-pyrene phosphatidylcholine, 1-palmitoyl-2-[(14)C]arachidonyl phosphatidylcholine ([(14)C]AA-PC), and [(3)H]arachidonic acid (AA). The methanol extracts s...

The essential oil obtained from the aerial parts of Marrubium deserti de Noé. (Lamiaceae), growing in the North fringe of the Algerian Sahara, was analyzed by GC-MS. Thirty-eight compounds were identified, representing 99.70% of the total oils. The GC-MS analysis revealed the presence of tetracosane, germacrene D, Δ-cadinene, α-cadinol and t-cadinol as the main constituents, representing 31.11%...

Ethylene glycol (EG) and methanol are responsible for life-threatening poisonings. Fomepizole, a potent alcohol dehydrogenase (ADH) inhibitor, is an efficient and safe antidote that prevents or reduces toxic EG and methanol metabolism. Although no study has compared its efficacy with ethanol, fomepizole is recommended as a first-line antidote. Treatment should be started as soon as possible, ba...

Liquefaction of sawdust was studied in methanol−water solutions using an acid catalyst under microwave energy. The effect of the methanol concentration on the changes of components in the liquefied products was analyzed by gas chromatography−mass spectrometry (GC−MS). It was found that 5-hydroxymethylfurfural (HMF) and levulinic acid are the dominate products using pure water as the liquefying ...

The present study was designated to evaluated the antimicrobial activities of methanol, ethanol, hexane, ethyl acetate, aqueous, mixture methanol/water and ethanol/water extracts of Pentadiplandra brazzeana, Erythrina sigmoïdea, Petersianthus macrocarpus, Clerodendrum umbellatum , Sida acuta , Eleusine indica , Bridelia micrantha and Musanga cecropioides which are plants used as traditional fol...

This study aimed to search for compounds with potential inhibitory activities towards DENV-2 replication. In vitro inhibitory activities of plant extracts towards DENV-2 replication were studied and the proteomics profile of cells infected with dengue virus, followed by treatment with plant extracts, were mapped out. Methanol crude and fractionated extracts of Quercus lusitanica were tested. Th...

The antimicrobial activity of crude tissue sample of sea star Astropecten indicus collected from Mudasal Odai, southeast coast of India was evaluated with the testing human microbial pathogens viz., Escherichia coli, Klebsiella pneumonia, K. oxytoca, Staphylococcus aureus, Streptococcus sp., Pseudomonas aeruginosa, Salmonella paratyphi and S. typhi using solvent system methanol and ethyl acetat...

BACKGROUND Gonorrhea is a major sexually transmitted disease worldwide and for its control, effective treatment is essential. However as more strains of Neisseria gonorrhoeae continuously develop resistance to several drugs, this strategy obliges scientists to discover newer effective drugs. OBJECTIVES To ascertain whether crude leaf and root extracts of Cassia alata (Caesalpiniaceae) have an...