BACKGROUND Low-dose dextromethorphan (DM) might have anti-inflammatory and neurotrophic effects mechanistically remote from an NMDA receptor. In a randomized, double-blind, controlled 12 week study, we investigated whether add-on dextromethorphan reduced cytokine levels and benefitted opioid-dependent patients undergoing methadone maintenance therapy (MMT). METHODS Patients were randomly assi...

BACKGROUND AND OBJECTIVES The goal of methadone maintenance treatment (MMT) is to reduce the harm and to improve patients' quality of life (Qol). However, the Qol is also influenced by other co-occurring disorders. Data regarding the Qol and the co-occurrence of these disorders is lacking in low-middle income countries. We therefore describe the prevalence of physical, psychiatric, and drug abu...

BACKGROUND Ensuring high enrollment while mobilizing resources through co-payment services is critical to the success of the methadone maintenance treatment (MMT) program in Vietnam. This study assessed the willingness of patients to pay (WTP) for different MMT services delivery models and determined its associated factors. METHODS A facility based survey was conducted among 1016 MMT patients...

This study aims to identify periods of elevated risk of drug-related mortality during methadone maintenance treatment (MMT) in primary care using a cohort of 3,162 Scottish drug users between January 1993 and February 2004. Deaths occurring during treatment or within 3 days after last methadone prescription expired were considered as cases "on treatment." Fatalities occurring 4 days or more aft...

Hyperalgesia is a common clinical phenomenon among opioid dependent patients on methadone maintenance therapy (MMT) and it may be associated with undertreated pain and/or therapeutic failure. This study aimed to investigate association between serum methadone concentration (SMC) and cold pressor pain responses. Cold pressor pain responses in 147 opioid dependent patients on MMT were assessed us...

BACKGROUND The low-threshold methadone maintenance treatment (MMT) programme in Hong Kong has been in place for about 40 years. Assessment of the participation pattern of methadone users may inform future programme development to achieve effective harm reduction. METHODS Longitudinal clinical data of methadone users who first registered for MMT in the year 2008 in Hong Kong were retrieved aft...

conclusions the major risk factor of hcv infection was injection drug use. the patient’s awareness of his or her hcv status had a minor effect in reduction of illicit drug use and improvement in mmt retention. therefore, adequate counseling is necessary for drug users in mmt clinics in xi’an. background hepatitis c virus (hcv) infection rates in drug users vary among different regions of china....

Background: Sleep disturbance is a common complaint of patients undergoing methadone maintenance therapy (MMT). There are limited studies about the effect of different treatments on insomnia due to MMT. In this study, we evaluated the effect of cognitive-behavioral treatment for insomnia (CBTI) on sleep disorders in patients undergoing MMT.Methods: Twenty-two patients with insomnia due to MMT (...