Metastatic tumors to the oro-facial region are uncommon accounting for 1 3% of all malignancies of the jaw and may occur in the oral soft tissues or jawbones. The clinical presentation of metastatic tumors can be variable, which may lead to erroneous diagnosis or may create diagnostic dilemma. We present the case of an 82 year-old man with metastatic adenocarcinoma of the prostate involving the...

Background: Prostate cancer is the second form of cancer among men worldwide. For early cancer detection, we should identify tumors in initial stages before the physical signs become visible. The present study aims to evaluate the diagnostic value of cell-free DNA (cfDNA), its comparison with prostate-specific antigen (PSA) level in prostate cancer screening and also in patients with localized ...

BACKGROUND Piwi-interacting RNAs (piRNAs) are small RNAs of 27-30 nucleotides mapping to transposons or clustering in repeat genomic regions. Preliminary studies suggest an important role in cancerogenesis. This study is the first one investigating their prognostic impact in clear cell renal cell cancer (ccRCC) patients. METHODS Three piRNAs (piR-30924, piR-57125, and piR-38756) selected on t...

intraocular metastatic tumors have been increasingly reported in the recent past. unlike choroidal metastasis, metastasis to retina is very rare and so far has been reported in very few case reports only. case presentation : a 56 year-old male who presented with a history of adenocarcinoma of the cecum and underwent lap colectomy for the primary cecal tumor, received adjuvant chemotherapy for a...

Adrenal collision tumors (ACTs), in which distinct tumors coexist without histological intermingling in the same adrenal gland, are rare and their actual prevalence is unknown. ACTs commonly consist of adrenal cortical adenoma, myelolipoma, or metastatic malignant tumor. We report a 58-year-old woman with a past history of breast cancer, who presented with a 1 month history of fevers, chills, a...

AIM To investigate the toxicity and outcome of stereotactic body radiotherapy (SBRT) for centrally-located lung tumors. PATIENTS AND METHODS A retrospective review was conducted in 45 consecutive patients with centrally-located lung tumors who underwent SBRT. The incidence rate of adverse events (AEs) and outcome after SBRT for primary (32 patients), metastatic and recurrent (13 patients) lun...

Metastatic disease is the main cause of cancer-related mortality due to almost universal therapeutic resistance. Despite its high clinical relevance, our knowledge of how cancer cell populations change during metastatic progression is limited. Here, we investigated intratumor genetic and phenotypic heterogeneity during metastatic progression of breast cancer. We analyzed cellular genotypes and ...

Background: Along with the increasing incidence of primary cancer, metastatic brain tumors are becoming more common. Metastatic tumor patients go through a great deal distress. Therefore, providing adequate standard therapy can alleviate patients’ clinical symptoms and improve their overall quality life. This study aimed to investigate role symptomatic treatments adjunctive psychotherapy in tum...

Purpose Malignant tumors are acidic. The extracellular pH of tumors ranges from 6.5-6.9 versus 7.2-7.4 in normal tissue. Acid-producing tumors are more invasive and exhibit a greater metastatic potential. Tumor acidity is toxic to the surrounding tissue, induces the breakdown of the basement membrane around the tumor, and increases expression and activity of metastatic effectors. Therefore, it ...