background: this study detected osteopontin (opn) and matrix metalloproteinase-7 (mmp-7) expressions to explore the roles of opn and mmp-7 in the occurrence, progression, and prognosis of nonsmall cell lung cancer (nsclc). materials and methods: a retrospective study was conducted on nsclc tissues ( n = 152; case group) and adjacent nonneoplastic lung parenchyma (adjacent to tumor >5 cm; n = 15...

A sequence of interconnected events known as the metastatic cascade promotes tumor progression by regulating cellular and molecular interactions between tumor, stromal, endothelial, immune cells both locally systemically. Recently, a new concept has emerged to better describe this process defining four attributes that should undergo. Every individual hallmark represents unique trait cell impact...

Objective(s): Blocking of vascular endothelial growth factor (VEGF) plays a pivotal role in inhibition of metastasis and is a target for development of anti-angiogenic agents. In this study, a peptide-based vaccine was designed and its potential for induction of humoral immune responses, generation of neutralizing antibodies, inhibition of tumor growth and metastasis w...

BackgroundSince the poor prognosis of uveal melanoma with distant metastasis, we intended to screen out possible biomarkers for metastasis risk and establish a nomogram model predicting (UVM) metastasis.MethodsTwo datasets UVM (GSE84976, GSE22138) were selected. Data was analyzed by R language, CTD database GEPIA.ResultsThe co-upregulated genes two datasets, HTR2B, CHAC1, AHNAK2, PTP4A3 identif...

Fatty acid-binding protein (FABP) 5 is highly expressed in various types of tumors and strongly correlated with tumor growth, development, metastasis. However, it unclear how the expression FABP5 host affects progression. In this study, using a lung metastasis model mice, we found that FABP5-deficient mice were more susceptible to metastasis, which accompanied by infiltration lower frequency ac...

A 7½-year-old girl is reported showing pre­cocious puberty and large abdominal mass for a year. The right ovarial cyst removed by surgery revealed histopathologically a granu­losa cell tumor. After removal of the tumor the estrogens were still increased and the signs of puberty showed no regression. This seems to be due to the hormonal activity of the metas­tases. Liver metastasis was present a...

Introduction: 18F-FDG PET/CT provides very effective results in detecting metastases of breast cancer. In our study, we investigated the relationship between maximum standard uptake value (SUVmax) and prognostic pathologic factors in breast cancer cases with isolated bone metastasis and whether there was any difference in terms of prognostic pathologic factors betwee...

testicular cancer typically spreads to the lymph nodes, but hematogenous dissemination to distant organs can also occur. bone metastasis is uncommon and is thought to be a poor prognostic indicator. jaw metastasis is exceedingly rare but is of great clinical significance, since it may be the first sign of an occult testicular cancer or the first evidence of relapse of a known tumor. herein, we ...