we evaluated the clinical experience of 120 women with early stage cervical cancer who underwent radical hysterectomy combined with pelvic lymphadenectomy (class iii rutledge) in our gynecologic oncology clinic. of these, 74 patient. (61.66%) were in stage i and 46 patients (38.34%) were in stage ii a. intraoperation complications comprised of great vessel injuries encountered in 4 (3.3%) patie...

ba c k g r o u nd: skin  metastases occur  in  1-5%  of  solid  tumors  and  are  rarely the presenting sign of internal malignancies. certain features in skin lesions raise suspicion of metastasis from solid tumors. c a s e presentation: in this article a 61-year-old woman is presented with erythematous skin nodules  in  upper  abdomen  and  chest. histopathological evaluation  of  lesions sug...

Osteoblastic bone metastases are common in prostate and breast cancer patients, but mechanisms by which tumor cells stimulate new bone formation are unclear. We identified three breast cancer cell lines that cause osteoblastic metastases in a mouse model and secrete endothelin-1. Tumor-produced endothelin-1 stimulates new bone formation in vitro and osteoblastic metastases in vivo via the endot...

Tumor metastases are the basic biological characteristics of malignant tumors, and the lungs are the second most prominent metastatic organs in which these develop after the liver. Currently, with the rapid development of ablation technology, ablation therapy as a local treatment is playing an increasingly important role in the treatment of lung metastases. Whether alone or in combination with ...

Background. The aim of this study was to show the importance of the bone marker procollagen type 1 aminoterminal propeptide (P1NP) in detecting bone metastases in women suffering from breast cancer. We furthermore investigated to what degree P1NP is correlated to the degree of bone metastases, and if P1NP is increased in patients with metastases other than bone. Patients and Methods. We analyze...

PURPOSE To evaluate the local tumor control rate and survival data for magnetic resonance (MR) imaging-guided laser ablation of breast cancer liver metastases by using laser-induced interstitial thermotherapy (LITT). MATERIALS AND METHODS MR-guided LITT was performed in 232 female patients with 578 liver metastases from breast cancer. Survival rates were calculated with the Kaplan-Meier metho...

BACKGROUND Insufficient information exists on the prognostic factors of papillary thyroid cancer (PTC) with chest metastases, which is detected only using a radioactive iodide (131I) whole body scan (WBS) but could not be detected using radiographic findings. The aim of this study was to analyze the clinical features and treatment results of patients with PTC. METHODS This retrospective study...

BACKGROUND Limited data exist on the impact of the site of metastases on survival in patients with stage IV prostate cancer (PCa). OBJECTIVE To investigate the role of metastatic phenotype at presentation on mortality in stage IV PCa. DESIGN, SETTING, AND PARTICIPANTS Overall, 3857 patients presenting with metastatic PCa between 1991 and 2009, included in the Surveillance Epidemiology and E...

In the current era of molecularly targeted therapies and precision medicine, choice of cancer treatment has been increasingly tailored according to the molecular or genomic characterization of the cancer the individual has. Previously, the clinical observation of inadequate control of brain metastases was widely attributed to a lack of central nervous system (CNS) penetration of the anticancer ...

CONTEXT Pancreatic neuroendocrine tumor (P-NET) is a rare and slow-growing tumor. Unfortunately, there is no clear consensus on the role and timing of surgery for primary tumor and liver metastases, although current reports refer to liver surgery including LT for unresectable liver metastases. CASE REPORT A thirty-nine-year-old man was diagnosed with nonfunctioning pancreatic neuroendocrine t...