OBJECTIVE : To assess the impact of past liver metastases on the survival duration of patients who are undergoing surgery for lung metastases. METHODS : We conducted a review of literature published from 2007 to 2014. The studies were identified by searching PubMed, MEDLINE, and Embase and were supplemented by a manual search of the references listed by the retrieved studies. The following se...

1. Reddy RH, Kumar B, Shah R, Mirsadraee S, Papagiannopoulos K, Lodge P, et al. Staged pulmonary and hepatic metastasectomy in colorectal cancer—is it worth it? Eur J Cardiothorac Surg. 2004;25:151–4. 2. Ambiru S, Miyazaki M, Ito H, Nakagawa K, Shimizu H, Kato A, et al. Resection of hepatic and pulmonary metastases in patients with colorectal carcinoma. Cancer. 1998;82:274–8. 3. Robinson BJ, Ri...

The oncological outcome after lung metastasis in patients with chondrosarcoma of the extremities has not been reported. Between June 2000 and June 2013, 179 patients with chondrosarcoma in the extremities were treated at eleven hospitals. Twenty consecutive patients (11.2%) developed lung metastases after initial treatment of primary chondrosarcoma in the extremities. We investigated the oncolo...

BACKGROUND Melanoma is highly curable in early stages but holds devastating consequences in advanced phases with a median survival of 6-10 months. Lungs are a common metastasis target, but despite this, limited data are available on the molecular status of pulmonary lesions. MATERIALS AND METHODS 25 patients with surgically resected melanoma lung metastases were screened for BRAF, NRAS, CKIT ...

Introduction. Patients with high-grade sarcoma (HGS) frequently develop metastatic disease thus limiting their long-term survival. Lung metastases (LM) have historically been treated with surgical resection (metastasectomy). A potential alternative for controlling LM could be stereotactic body radiation therapy (SBRT). We evaluated the outcomes from our institutional experience utilizing SBRT. ...

BACKGROUND Pulmonary metastasectomies are performed for a variety of cancers, though few reports have examined their merit for head and neck cancers. This study examined the relationship between clinical and pathological characteristics and survival after resection of lung metastases of these cancers. METHODS Between 1986 and 2013, 34 patients presenting with pulmonary metastases of primary h...

Direct immune activation via agonisticmAbs is a potentially complementary approach to therapeutic blockade of inhibitory immune receptors in cancer. Here, we provide genetic analysis of the immunologic consequences associated with the use of an agonistic CD40 mAb in a patient with metastatic melanoma who responded, underwent a single metastasectomy, and then achieved a complete remission ongoin...