نتایج جستجو برای: metalloproteinase
تعداد نتایج: 20510 فیلتر نتایج به سال:
Background: Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It a infection primarily targeting the system. However, many other extrapulmonary body organs are also
 affected with varying degree of severity. Some evidence indicated development periodontist in patients, although pathogenesis not well-defined.
 Aims: This study ...
To study the interaction of lymphocytes and macrophages in the control of extracellular matrix turnover, we determined the effects ofseveral solubleT cell products on mononuclear phagocyte production of metalloproteinases. Cytokines including IL2, IL4, IL-6, tumor necrosis factor a (TNFa), GM-CSF, and IFN-gamma were each tested for capacity to modulate macrophage metalloproteinase and tissue in...
Matrix metalloproteinase-9 is elevated within the acutely injured murine spinal cord and blockade of this early proteolytic activity with GM6001, a broad-spectrum matrix metalloproteinase inhibitor, results in improved recovery after spinal cord injury. As matrix metalloproteinase-9 is likewise acutely elevated in dogs with naturally occurring spinal cord injuries, we evaluated efficacy of GM60...
OBJECTIVE To assess the ability of matriptase, a type II transmembrane serine proteinase, to promote aggrecan loss from the cartilage of patients with osteoarthritis (OA) and to determine whether its inhibition can prevent aggrecan loss and cartilage damage in experimental OA. METHODS Aggrecan release from human OA cartilage explants and human stem cell-derived cartilage discs was evaluated, ...
Dry eye disease (DED) is a condition of the ocular surface characterized by tear film abnormalities and symptoms; inflammation principal pathogenesis. Recently, matrix metalloproteinase-9 (MMP-9) point-of-care immunoassay (InflammaDry) has become widely used as an ancillary diagnostic tool in routine clinical settings. This paper reviews role MMP-9 DED, relationships MMP-9-positivity on Inflamm...
Adaptive responses to arterial/arteriolar pressure elevation have typically been investigated in cross-sectional studies hypertensive patients or longitudinal experimental animals. The present investigation shows that healthy individuals, fifteen 40-min, carefully controlled, moderate transmural elevations markedly increase vivo stiffness (i.e. reduce distension) arteries and arterioles. respon...
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