Metabolic diseases are becoming more common and severe in populations adhering to western lifestyle. Since metabolic conditions highly diet lifestyle dependent, it is suggested that certain diets the cause for a wide range of dysfunctions. Oxidative stress, excess calcium excretion, inflammation, acidosis features origins most disease. These primary manifestations “metabolic syndrome” can lead ...

Obstructive sleep apnoea syndrome (OSAS) is a sleep disorder that leads to metabolic abnormalities and increased cardiovascular risk. This study aimed to define the expression and clinical significance of biomarkers involved in oxidative stress in patients with OSAS. A prospective study was designed to compare outcomes of oxidative stress laboratory tests in three groups of subjects. The study ...

Obesity now affects millions of people and places them at risk of developing metabolic syndrome, nonalcoholic fatty liver disease (NAFLD), and even hepatocellular carcinoma. This rapidly emerging epidemic has led to a search for cost-effective methods to prevent the metabolic syndrome and NAFLD as well as the progression of NAFLD to cirrhosis and hepatocellular carcinoma. In murine models, time...

Obesity and metabolic syndrome are associated with mitochondrial dysfunction and deranged regulation of metabolic genes. Peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β) is a transcriptional coactivator that regulates metabolism and mitochondrial biogenesis through stimulation of nuclear hormone receptors and other transcription factors. We report that the PGC-1β gene encode...

INTRODUCTION Type 2 Diabetes Mellitus (T2DM) is often associated with devastating diabetic complications: nephropathy, retinopathy, coronary artery disease, cerebrovascular disease, peripheral vascular disease, and neuropathy. Hypertension is a common co-morbidity in diabetes mellitus, therefore the consequences of high blood pressure on T2DM should be considered. Among diabetics, hypertension ...

High dietary fructose is a major contributor to insulin resistance and metabolic syndrome, disturbing tissue and organ functions. Fructose is mainly absorbed into systemic circulation by glucose transporter 2 (GLUT2) and GLUT5, and metabolized in liver to produce glucose, lactate, triglyceride (TG), free fatty acid (FFA), uric acid (UA) and methylglyoxal (MG). Its extrahepatic absorption and me...

Oxidative stress after major surgeries is associated with the development of poor clinical outcomes including delayed wound healing and increase in Pediatric Intensive Care Unit (PICU) length of stay. Due to the growth and development phase in childhood, the change in the levels of oxidative stress and inflammation is of high importance in these patients. Notably, the acute metabolic stress whi...

Despite pathophysiological similarities to alcoholic liver disease, susceptibility to acetaminophen hepatotoxicity in metabolic syndrome-related nonalcoholic steatohepatitis (NASH) has not been well elucidated. In this study, therefore, we investigated acetaminophen-induced liver injury in KK-A(y) mice, an animal model of metabolic syndrome. Twelve-week-old male KK-A(y) and C57Bl/6 mice were in...

Metabolic syndrome and its components are associated with chronic kidney disease (CKD) development. Insulin resistance (IR) plays a central role in the metabolic syndrome and is associated with increased risk for CKD in nondiabetic patients. IR is common in patients with mild-to-moderate stage CKD, even when the glomerular filtration rate is within the normal range. IR, along with oxidative str...

Alzheimer’s disease (AD) represents a significant public health concern in modern society. Metabolic syndrome (MetS), which includes diabetes mellitus (DM) and obesity, modifiable risk factor for AD. MetS AD are interconnected through various mechanisms, such as mitochondrial dysfunction, oxidative stress, insulin resistance (IR), vascular impairment, inflammation, endoplasmic reticulum (ER) st...