Z-100 is an arabinomannan extracted from Mycobacterium tuberculosis that has various immunomodulatory activities, such as the induction of interleukin 12, interferon gamma (IFN-gamma) and beta-chemokines. The effects of Z-100 on human immunodeficiency virus type 1 (HIV-1) replication in human monocyte-derived macrophages (MDMs) are investigated in this paper. In MDMs, Z-100 markedly suppressed ...

Speech in everyday conversations is riddled with discourse markers (DMs), such as well, you know, and like. However, many lab-based studies of speech comprehension, DMs are typically absent from the carefully articulated highly controlled stimuli. As such, little known about how these influence online word recognition. The present study specifically investigated processing DM like it influences...

The macrophage mannose receptor (MR) along with complement receptors mediates phagocytosis of the M. tuberculosis virulent strains Erdman and H37Rv. We have determined that the terminal mannosyl units of the M. tuberculosis surface lipoglycan, lipoarabinomannan (LAM), from the Erdman strain serve as ligands for the MR. The biology of the MR (receptor binding and trafficking) in response to phag...

We report a study of a class of 28 sixth graders engaged in an extended computer-supported argumentive discourse activity. Participants collaborated with a same-side peer in arguing against successive pairs of peers on the opposing side of an issue. Meta-level awareness was facilitated by conducting the dialogs via instant messaging software, which made available a transcript of the dialog that...

This paper presents and motivates a methodology for conducting semantic fieldwork on languages of the Americas. I first argue that one cannot gather adequate information about meaning from spontaneous discourse alone. Thus, direct elicitation (including asking consultants for judgments) is an indispensable methodological tool. I then present more detailed methodological suggestions. I offer tec...

Macrophages are the major cell type observed in the inflammatory membrane retrieved at implant revision surgery. In this study, mature human monocyte-derived macrophages (MDM) were adapted to a previously established in vitro model to examine the influence of high-density polyethylene (HDPE) particulate (4-10 microm) on MDM viability. HDPE particles were suspended in soluble type I collagen, wh...

BACKGROUND AND PURPOSE MicroRNAs are small non-coding RNAs with 19-24 nucleotides in length. Up- or down-regulation of many miRNAs has been shown by stimulation of Toll-like receptors (TLRs) in the innate immune system. Up-regulation of miR-146a has been reported by both TLR and heat-killed Candida albicans. In this study, we aimed to evaluate the expression of miR-146a in cultured monocyte-der...

Automatic extraction of key sentences from academic presentation speeches is addressed. The method makes use of the characteristic expressions used in initial utterances of sections, which are defined as discourse markers and derived in a totally unsupervised manner based on word statistics. The statistics of the discourse markers are then used to define the importance of the sentences. It is a...