Glioblastoma is composed of dividing tumor cells, stromal cells and tumor initiating CD133+ cells. Recent reports have discussed the origin of the glioblastoma CD133+ cells and their function in the tumor microenvironment. The present work sought to investigate the multipotent and mesenchymal properties of primary highly purified human CD133+ glioblastoma-initiating cells. To accomplish this ai...

Abstract Background Acute liver failure (ALF) is an acute inflammatory disease with high mortality. Previous preclinical and clinical trials have confirmed that mesenchymal stem cell (MSC) a promising therapeutic approach; however, the effect not satisfied as underlying molecular mechanisms of MSC in treating ALF remain unclear. Methods isolated from 4- to 6-week-old C57BL/6 mice were used trea...

Background : Burn injury is a trauma with high morbidity and mortality that requires special management from the start. stem cells have generated great hopes for treatment of numerous conditions including burns. The Metaanalysis was performed these preclinical studies to assess efficacy possible mechanisms Amniotic Membrane Mesenchymal Stem Cell (AM-MSC) in treating burn wounds.Methods: . Seven...

tissue engineering based on the adipose derived stem cells  promote a strong strategy to propagation of bone, cartilage and fat tissues in the three-dimensional scaffolds, fabricated by combining biological materials with suitable and appropriate growth factors.  in this study, a peo scaffold was used to show that mesenchymal stem cells can attach well; the aim of this study was the investigati...

Mesenchymal stem cells (MSC) mediate their immunosuppressive effects via a variety of mechanisms. One of these mechanisms involves the induction of macrophages with immunomodulatory capacities. This effect of MSC may be exploited when MSC are used as a cell therapeutic product. Furthermore, MSC are resident in tissues where they may locally target infiltrating macrophages to adapt more regulato...

objective: the development of combining mesenchymal stem cells (mscs) with surface modified three-dimensional (3d) biomaterial scaffold provides a desirable alternative for replacement of damaged and diseased tissue. nanofibrous scaffolds serve as suitable environment for cell attachment and proliferation due to their similarity to the physical dimension of the natural extracellular matrix. in ...

An immortalized murine mesenchymal stem cell line (mTERT-MSC) enriched for Lin(neg)/Sca-1(pos) fraction has been obtained through the transfection of MSC with murine TERT and single-cell isolation. Such cell line maintained the typical MSC self-renewal capacity and continuously expressed MSC phenotype. Moreover, mTERT-MSC retained the functional features of freshly isolated MSC in culture witho...

AIMS The heart contains c-kit(+) progenitors that maintain cardiac homeostasis. Cardiac c-kit(+) cells are multipotent and give rise to myocardial, endothelial and smooth muscle cells, both in vitro and in vivo. C-kit(+) cells have been thoroughly investigated for their stem cell activity, susceptibility to stress conditions and ageing, as well as for their ability to repair the infarcted heart...

Intervertebral disc (IVD) degeneration accounts for most cases of low back pain, which usually starts from the inner nucleus pulposus (NP) area. Increasing investigation into NP regeneration highlights mesenchymal stem cells (MSC) as a potential stem cell source to repopulate the damaged and dehydrated NP. Despite the majority of researches investigate the role of MSC derived from bone marrow, ...