Background and Objectives: Alzheimer's disease (AD) is a neurodegenerative disease and the most common cause of dementia. The characteristics of this disease are amnesia, cognitive and verbal disorders, memory deficit, paranoia, depression, and anxiety. In this study, the alterations of cognitive-behavioral and nuclear factor kappa (NF-κ) factor, were investigated following the xenogenic transp...

Introduction: Oleuropein is the most important phenolic compound in olive leaves which has several pharmacological properties. So far, this compound has been shown to have antioxidant, anti-inflammatory, anti-atrogenic, antimicrobial, and antiviral properties. Scopolamine is a muscarinic antagonist used as standard medication for inducing cognitive deficits in humans and animals. This study was...

hydrochlorothiazide (hct) is a diuretic agent which is shown to be effective in the treatment of hypertension. literature reports have demonstrated that urinary excretion data may be used to assess the bioavailability of various formulations containing this thiazide. also hct consumption by the athletes is one of the drugs which should be regulated by world anti-doping agency (wada), because of...

Background and Objective: One of the characteristics of human is their ability to change behavior based on previous experiences. Learning is the acquisition of information that makes this possible, and memory is meant to store this information. Millet contains proteins, minerals, vitamins and antioxidants needed to preserve the life and health of mammalian cells. This study was conducted to de...

Background and Objective: Diabetes is a chronic metabolic disorder and oxidative stress plays an important role in the development of diabetic complications such as learning and memory impairment. Since Lavendula species improve learning and memory and Lavandula dentata contains antioxidant and anti-inflammatory effects and it is used as ustokhoddus in Iran, we have designed this research to st...

Background: Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by abnormal protein accumulation, synaptic dysfunction, and cognitive impairment. Peroxisome proliferator-activated gamma receptors (PPARγ) play a crucial role in regulating insulin sensitivity and may serve as potential therapeutic targets for AD. Pioglitazone (Piog) as a PPARγ   agonist reduce β-amyloid ...