The mel-32 gene in the free living soil nematode Caenorhabditis elegans encodes a serine hydroxymethyltransferase (SHMT) isoform. Seventeen ethylmethanesulfonate (EMS)-induced mutant alleles of mel-32(SHMT) have been generated, each of which causes a recessive maternal effect lethal phenotype. Animals homozygous for the SHMT mutations have no observable mutant phenotype, but their offspring dis...

The indolamine melatonin (MEL) is described as an antioxidant and a free radical scavenger. However occasionally, the indoleamine has been reported to increase free radicals with insufficient mechanistic explanation. In an attempt to find a reason for those controversial results, a potential mechanism that explains MEL prooxidant activity is investigated. The current controversy about redox det...

The aim of this article was to study the trans-epithelial absorption to reach the blood and to target the brain by axonal transport using nasal formulations with nanonized meloxicam (nano MEL spray) and its salt form known as meloxicam potassium monohydrate (MELP spray). The physicochemical properties and the mucoadhesivity of nasal formulations were controlled. In vitro and in vivo studies wer...

The aim of this study was to assess the applicability of Mel Frequency Cepstral Coefficients (MFCC) of voice samples in diagnosing vocal nodules and polyps. Patients’ voice samples were analysed acoustically with the measurement of MFCC and values of the first three formants. Classification of mel coefficients was performed by applying the Sammon Mapping and Support Vector Machines. For the tes...

173 xxx both display linear pharmacokinetics in the dose range(s) usually employed. Furthermore, the good central nervous system (CNS) penetration of both Bu and Mel and their relative non-overlapping clinical toxicity profiles should make this combination an effective, high-dose chemotherapy regimen. In the autologous setting,(4,5) BU plus Mel as conditioning regimen prior to ASCT has been adm...

O presente estudo toma como proposta de reflexão a realidade da Educação Básica brasileira que revela, segundo estatísticas do Programa Internacional Avaliação Alunos (PISA) - 2018, problemas consideráveis em relação à competência leitora dos estudantes. Considerando perspectiva teórica Semântico-Enunciativa Guimarães (2002, 2018), propõe o Método Enunciativo Leitura (MEL) enquanto pedagogia mu...

Epidermal growth factor receptors 2 (Her-2) and 4 (Her-4) are closely associated with ovarian cancer (OC) progression and metastasis, and a more complete understanding of these signaling pathways allow the development of new therapeutic strategies. Melatonin (Mel) is recognized as having several anticancer properties and has been reported to modulate Her-2 system in aggressive tumors. Here, we ...

In the pineal, melatonin (Mel) is synthesized from serotonin by arylalkylamine-N-acetyltransferase (AA-NAT) and hydroxyindole-O-methyltransferase (HIOMT). Although it is clear that AA-NAT drives the daily rhythm in Mel synthesis, the mechanisms involved in the photoperiodic changes of the amplitude of the Mel peak, as observed in the Siberian hamster, remain to be determined. We investigated th...

We have previously described the gene mei-1, which encodes an essential component of the Caenorhabditis elegans meiotic spindle. When ectopically expressed after the completion of meiosis, mei-1 protein disrupts the function of the mitotic cleavage spindles. In this article, we describe the cloning and the further genetic characterization of mel-26, a postmeiotic negative regulator of mei-1. me...

PURPOSE Renal ischemia reperfusion (IR) is an important cause of renal dysfunction. It contributes to the development of acute renal failure (ARF). The purpose of this study was to investigate the anti-inflammatory effect of erythropoietin (EPO) and melatonin (MEL), which are known anti-inflammatory and antioxidant agents, in IR-induced renal injury in rats. METHODS Male Wistar Albino rats we...