CUTELY DEPRESSED erythropoiesis in a decompensated hemolytic disorder such as sickle cell anemia results in a rapid fall in hematocrit which can be fatal if not promptly treated. Such intermittent inhibition of marrow activity has been previously reported in association with superimposed acute infection2123 and nutritional deficiency.hI More recently, the observation of megaloblastic maturation...

INTRODUCTION Although vitamin B12 deficiency is a well-known cause of hematological and neuropsychiatric illness, the presentation of combined severe pancytopenia, demyelination and prominent psychiatric impairment is rare. CASE PRESENTATION We present a case of a previously healthy 55-year-old East African man with severe vitamin B12 deficiency (serum vitamin B12 22pmol/L) secondary to perni...

Neutrophil hypersegmentation is an expected peripheral blood smear finding in megaloblastic anemias. But some clinical reports suggest that neutrophil hypersegmentation may also occur in patients with iron deficiency anemia. In this study we searched the presence of neutrophil hypersegmentation and thrombocytosis in patients with iron deficiency anemia but who had normal serum vitamin B12 and f...

OBJECTIVE To review the experience of patients presenting with clinical manifestations of tropical sprue and assess their diagnosis and management, response to treatment and follow up. METHODS This single center retrospective descriptive study was done at Shifa International Hospital, Islamabad from January 1994 to January 2003. All patients who presented with diarrhea, anorexia, weight loss ...

Background: Anemia is a major nutritional problem worldwide especially in developing countries. This research was conducted to find the incidence of severe anemia, identify common clinical features and etiology it assess requirement packed red cell transfusion. Methods: All patients having anemia (hemoglobin <7 gm/dl 6-59 months <8 5-14 years as per WHO definition) between 6-14 were inclu...

Thrombocytopenia is the reduction of platelet number to below normal level. It may be due to the decrease in production, increase in destruction, abnormal spreading in the body or the laboratory errors. B12 deficiency is a rarely seen vitamin deficiency in childhood. It presents with megaloblastic anemia and is difficult to diagnose because of various clinical findings. Here we would like to pr...