STUDY QUESTION Does medroxyprogesterone acetate (MPA) impair human dendritic cell (DC) activation and function? SUMMARY ANSWER In vitro MPA treatment suppressed expression of CD40 and CD80 by human primary DCs responding to Toll-like receptor 3 (TLR3) agonist stimulation (i.e. DC activation). Moreover, this MPA-mediated decrease in CD40 expression impaired DC capacity to stimulate T cell prol...

CONTEXT Depot medroxyprogesterone acetate (DMPA), which has a high rate of use among teenagers in Europe and the United States, has been associated with impaired bone mineral acquisition during adolescence and accelerated bone loss in later life. Studies on the association between DMPA use and fracture risk are limited. OBJECTIVE We aimed at evaluating the relationship between use of hormonal...

The heat of dissolution of cellulose in one imidazolium acetate ionic liquid was determined experimentally. The value of -132 ± 8 J g(-1) indicates that the dissolution is exothermal thus confirming energetically favourable cellulose-ionic liquid interactions but indicating that an increase in temperature does not thermodynamically favour the dissolution process.

The title compound, C(16)H(17)NO(5)S, was one of two condensation products from the reaction of 1-(1,3-benzothia-zol-2-yl)propan-2-one with methyl chloro-acetate. The non-H atoms in each of the four substituent groups on the central quaternary C atom are virtually coplanar. The maximum deviations from the least-squares planes are 0.015 (2) and 0.020 (2) Å for the methyl C atoms in the methyl ac...

Kinetic studies for the non-isothermal decomposition of unirradiated and γ-irradiated silver acetate with 10(3) kGy total γ-ray doses were carried out in air. The results showed that the decomposition proceeds in one major step in the temperature range of (180-270 °C) with the formation of Ag(2)O as solid residue. The non-isothermal data for un-irradiated and γ-irradiated silver acetate were an...

The rate of hydrolysis of esters in solution is highly dependent on the nature of the alcohols, e.g. hydrolysis of methyl acetate is twice as fast as that of ethyl, n-propyl and n-butyl acetate and six times as fast as that of i8opropyl acetate (Smith & Olsson, 1925). The fact that the different wool esters hydrolyse at approximately the same rate suggests that the rate-controlling step in the ...

Flecainide acetate [ 2,5-di(2,2,2-trifluoroethoxy ) -N(2-piperidylmethyl) benzamide acetate; Tambocor@ ] has been shown to markedly suppress ventricular and supraventricular rhythm disorders [l-7]. Effective serum levels of flecainide range from ca. 0.2 to 1.0 pg/ml [1,3,6-g]. Although the antiarrhythmic efficacy of flecainide acetate is not correlated directly with its serum level, the determi...

Material and Methods: A total of 24 female Wistar rats were divided into two groups. The control group received saline, and the second group was administered medroxyprogesterone acetate in the therapeutic dose of 30 mg/kg bw. The substances were applied daily, intramuscularly for a period of 7 days. Paraffin sections of thymus were dyed with the following methods: hematoxylin eosin and elastica...