The quinoline core structure is an important heterocyclic feature that can be found in numerous biologically active componds which exhibit a vast range of pharmacological properties such as antimalarial [1], antibacterial [2], antimicrobial [3], and antistaphylococcal activities [4]. Meanwhile, an important class of antibiotics possesses a 4-quinolone framework in their structure [5], and also ...

In this paper I shall argue that the search for fundamental knowledge, motivated by curiosity, is as useful as the search for solutions to specific problems. The reasons we have practical computers now, and did not have them 100 years ago, is not that meanwhile we have discovered the need for computers. It is because of discoveries in fundamental physics which underwrite modern electronics, dev...

As we’ve mentioned, there’s plenty of reason to believe that the overexcited cop thought that he was firing his Taser. That’s a conclusion that even the victim’s attorney implicitly conceded. “It doesn't matter if he was reaching for a Taser or not. At the end of the day, it's what [the officer] did that counts.” Meanwhile nervous BART officials avoided all talk of race and promised what bureau...

Various strategies have been developed to exploit plants as bioreactors for the production of pharmaceutical antibodies, to engineer antibody-mediated pathogen resistance or to alter the plant phenotype by immunomodulation. Recent research developments focus on the fine-tuning of expression systems and the detailed characterisation of recombinant products, including the implications of plant-sp...

The exchange bias (EB) effect was discovered 60 years ago by Meiklejohn and Bean. Meanwhile the EB effect has become an integral part of modern magnetism with implications for basic research and for numerous device applications. The EB effect was the first of its kind which relates to an interface effect between two different classes of materials, here between a ferromagnet and an antiferromagn...

Structuring the innovation process and managing multifunctional teams is a basic prerequisite successful innovation. A well-structured process gives the possibility to implement effective multifunctional teamwork. Meanwhile, multifunctional teamwork helps to optimise and accomplish the innovation process. Organizational support is necessary to achieve effective teamwork. Designing or changing t...

Using Riordan arrays, we introduce a generalized Delannoy matrix by weighted Delannoy numbers. It turn out that Delannoy matrix, Pascal matrix, and Fibonacci matrix are all special cases of the generalized Delannoy matrices, meanwhile Schröder matrix and Catalan matrix also arise in involving inverses of the generalized Delannoy matrices. These connections are the focus of our paper. The half o...

The human dynamics of relocation , meanwhile, are more complex than in the past. With the prevalence of two-career families, relocation often affects not one but two careers. Recognizing the difficulty of relocating two-career couples, employers may consider single job candidates better suited for relocation. This myth, however, is rapidly exploding. Many single people now are reluctant to leav...

The Schwarz alternating algorithm, which is based on natural boundary element method, is constructed for solving the exterior anisotropic problem in the three-dimension domain. The anisotropic problem is transformed into harmonic problem by using the coordinate transformation. Correspondingly, the algorithm is also changed. Continually, we analysis the convergence and the error estimate of the ...

We estimate a mixed logit demand model for the Japanese digital content market and measure willingness to pay for service attributes. We find that the willingness to pay for an extra unit of service quality ranges from 62 Yen to 83 Yen per month. Meanwhile, the switching cost, a measure of disutility from switching to other service providers is estimated as 340 Yen ($3) per month, which is appr...