OBJECTIVE To compare long-term outcomes following microwave endometrial ablation (MEA™) and thermal balloon ablation (TBall). DESIGN Follow up of a prospective, double-blind randomised controlled trial at 5 years. SETTING A teaching hospital in the UK. POPULATION A total of 320 women eligible for and requesting endometrial ablation. METHODS Eligible women were randomised in a 1:1 ratio ...

The collection of good quality extracellular neuronal spikes from neuronal cultures coupled to Microelectrode Arrays (MEAs) is a binding requirement to gather reliable data. Due to physical constraints, low power requirement, or the need of customizability, commercial recording platforms are not fully adequate for the development of experimental setups integrating MEA technology with other equi...

l-Glutamate (Glu) is the main excitatory neurotransmitter in the mammalian central nervous system, and it is involved in most aspects of normal brain function, including cognition, memory and learning, plasticity, and motor movement. Although microdialysis techniques have been used to study Glu, the slow temporal resolution of the technique may be inadequate to properly examine tonic and phasic...

Mass spectrometry (MS) is the enabling technology for proteomics and metabolomics. However, dramatic improvements in both sensitivity and throughput are still required to achieve routine MS-based single cell proteomics and metabolomics. Here, we report the silicon-based monolithic multinozzle emitter array (MEA) and demonstrate its proof-of-principle applications in high-sensitivity and high-th...

In contrast to the extensive use of microelectrode array (MEA) technology in electrophysiological studies of cultured neurons and cardiac muscles, the vast field of skeletal muscle research has yet to adopt the technology. Here we demonstrate an empowering MEA technology for high quality, multisite, long-term electrophysiological recordings from cultured skeletal myotubes. Individual rat skelet...

Antibodies have widespread applications in areas ranging from therapeutics to chromatography and protein microarrays. Certain applications require only the fragment antigen-binding (Fab) units of the protein. This study compares the cleavage efficacy of dithiothreitol (DTT), mercaptoethylamine (MEA), and dithiobutylamine (DTBA) - a relatively new reducing agent synthesized in 2012. Pseudo-first...

To study the BOLD effect numerically, blood vessels are often modelled as infinite cylinders [1] (infinite cylinder model, ICM). To simplify analytical calculations, signal dephasing resulting from spins diffusing around these infinite cylinders is then usually further approximated as a mono-exponential signal decay as suggested by Ogawa et al.[1]. Although for a wide range of parameters this m...

OBJECTIVE Deficits in social recognition and learning of social cues are major symptoms of neurodegenerative disorders such as Alzheimer's disease (AD). Here we studied the role of β1-noradrenergic signaling in cognitive function to determine whether it could be used as a potential therapeutic target for AD. METHODS Using pharmacological, biochemical and behavioral tools, we assessed social r...

This study was carried out to determine the palmitoylethanolamide (PEA) and arachidonoylethanolamide (AEA) or anandamide contents in selected fish wastes, treating wastes with highest PEA AEA different concentration of monoethanolamine (MEA) solution, incubation temperature time, as well ratio MEA solution waste further increase its contents.
 Based on results preliminary experiment, a fra...

Rapid and accurate inversion of soil salinity is a key scientific problem that needs to be solved urgently. Due the accuracy UAV multispectral remote sensing based on back propagation neural network (BPNN) low, in this study, used image field measurements 60 surface as data sources, 16 indexs were constructed using extracted spectral reflectance, performed gray relation analysis screen index fe...