We have demonstrated that, in addition to their contractile function, human airway smooth-muscle cells (HASMC) are able to express and to secrete chemokines of the monocyte chemotactic protein (MCP)/ eotaxin subfamily. This group of chemokines is believed to play a fundamental role in the development of allergic airway diseases such as asthma. The expression levels of MCP (MCP-1, -2, and -3) me...

Monocyte chemoattractant protein-1 (MCP-1) mediates monocyte migration into tissues in inflammatory diseases and atherosclerosis. We have investigated structure-activity relationships for human MCP-1. Mutations were introduced based upon differences between MCP-1 and the structurally related but functionally distinct molecule interleukin-8 (IL-8). Mutant proteins produced using the baculovirus/...

Although monocyte chemotactic protein-1 (MCP-1) is best known for its ability to recruit mononuclear cells, few studies have examined the effects of this chemokine on other events in the vascular response to injury. The purpose of the present study was to determine the influence of MCP-1 on human vascular smooth muscle (VSMC) proliferation. MCP-1 induced concentration-dependent VSMC proliferati...

BACKGROUND AND PURPOSE It is well documented that oxidized low-density lipoproteins (LDLs) can stimulate human vascular endothelial cells to produce monocyte chemoattractant protein-1 (MCP-1). Vitamin C is known to be an important antioxidant for vasodilatation. The purpose of this study was to determine whether pretreatment with vitamin C could protect against oxidized-LDL-induced expression o...

The heterogenous mineralogy of ultramafic deposits hosting mining operations makes it challenging to accurately determine the waste rock’s mineral carbonation potential (MCP). Additionally, significantly higher capabilities olivine than serpentine add difficulty. To address this issue, in work, a new and unique tool called MCP calculator was developed as Microsoft ExcelTM spreadsheet amount ant...

Process capability indices (PCIs) have been widely used in industries for assessing the capability of manufacturing processes. Castagliola and Castellanos (Quality Technology and Quantitative Management 2005, 2(2):201–220), viewing that there were no clear links between the definition of the existing multivariate PCIs and theoretical proportion of nonconforming product items, defined a bivariat...

We concern ourselves in this paper with formalization of conditional preferences based on modal logic. We indicate four basic requirements for the task and show that meeting them jointly presents a challenge to existing dyadic modal logics of preferences. As an alternative, we introduce a minimal system, MCP, of triadic modal logic, which is consistent and also frame sound and frame complete wi...

Abstract A systematic investigation of Planacon MCP-PMTs was performed using 64 XP85002/ FIT-Q photosensors. These devices are equipped with microchannel plates reduced resistance. Results a study their gain stability over time and saturation level in terms the average anode current presented. This information allows one to determine lower limit MCP resistance for stable operation. The spread e...

A strain of Mycobacterium bovis BCG that secretes high levels of functional murine monocyte chemotactic protein 3 (BCG(MCP-3)) was developed. Mice vaccinated with BCG(MCP-3) displayed increased lymphocyte migration in vivo and augmented antigen-specific T-cell responses compared to mice vaccinated with BCG alone. The level of protection afforded by BCG(MCP-3) was equivalent to that with control...

IgE was measured by ELISA in tubes and in microtiter plates, the results being compared with PRIST data. The recommended readings of the tube contents in a spectrophotometer (SPM) were compared with results using a multi-channel photometer (MCP). Geometric mean values (International Units) and standard deviations of 44 normal sera examined by the 3 different methods were: PRIST 16.2 +/- 4.0; SP...