The in vitro activity of HR 756, a new cephalosporin, has been determined against recent clinical isolates and compared with that of other beta-lactam antibiotics. The geometric means of the minimum inhibitory concentrations (MIC) for different isolates of Escherichia coli (100 isolates), Klebsiella pneumoniae (84), Pseudomonas aeruginosa (121), Proteus mirabilis (52), indole-positive Proteus s...

In a prospective study we compared two different dosage regimens of IV chloramphenicol succinate (100 mg/kg/day and 75 mg/kg/day) in children with culture proven typhoid. Trough and peak blood samples, obtained at 48 hrs, were analysed for free chloramphenicol by high pressure liquid chromatography (HPLC). Although the mean trough (8.8 +/- 7.7 versus 5.4 +/- 2.6 mcg/ml) and peak (19.9 +/- 12.2 ...

Mutations in the gene encoding the methyl-CG binding protein MeCP2 cause several neurological disorders including Rett syndrome. The di-nucleotide methyl-CG (mCG) is the classical MeCP2 DNA recognition sequence, but additional methylated sequence targets have been reported. Here we show by in vitro and in vivo analyses that MeCP2 binding to non-CG methylated sites in brain is largely confined t...

Combination treatment with intravenous immunoglobulin (IVIG) plus prednisolone is effective for prevention of cardiovascular complications in children with Kawasaki disease (KD). However, administration of prednisolone for approximately 20 d in this regimen causes adrenocortical suppression in a high proportion of treated children. To establish a simple method to screen for this suppression, we...

sinus, Der p 1; Dermatophagoides farinae, Der f 1), and Felis domesticus (Fel d 1), Canis familiaris (Can f 1), Blattella germanica (Bla g 2). Quantification of these allergens was performed on a multiplexing instrument, Luminex 200, (Luminex Corporation, Austin, TX). Results: Samples from 63 MF and 69 LA were returned. There was a statistical significance in total DM levels between both locati...

Plasma and skin concentrations of orbifloxacin (Orbax tablets, Schering-Plough Animal Health) were assessed in 14 clinically normal dogs and 14 dogs with pyoderma following oral administration of the drug at 7.5 mg/kg once daily for 5 to 7 days. Skin biopsies and whole blood samples were obtained before dosing and at the time of the expected maximum concentration in skin (3 hours after dosing) ...

Case reports Case 1. 70 years old woman, with history of severe persistent asthma for 10 years was referred to our allergy clinic. She could not control her asthma and asthmatic attack always happened at night, so it was worse when she slept. She was treated with fluticasone/salmeterol accuhaler (250/50 mcg) 2 puffs twice daily, montelukast (10 mg), theophylline (200 mg), procaterol (50 mcg) an...

BACKGROUND An analysis of the US National Cardiovascular Data Registry has revealed that only 38% of patients referred for coronary angiography after non-invasive coronary testing have relevant coronary obstruction (CO) (≥70%) of one or more coronary arteries. METHODS A single-center trial was undertaken in 165 consecutive, symptomatic patients with either known or suspected coronary disease ...

Hausfater and colleagues stated that in febrile adult patients presenting to the emergency department (ED) a procalcitonin (PCT) ≥0.2 mcg/l can help physicians to identify bacterial/parasitic infections [1]. We disagree and want to illustrate that by calculating likelihood ratios (LR). A LR is a semi-quantitative measure of the performance of a diagnostic test, expressing the magnitude by which...

CONTEXT Analgesia and sedation are required for the comfort of patient and the cardiologist during balloon mitral valvotomy. AIMS In this study, efficacy of analgesia, sedation, and patient satisfaction with sufentanil was compared with fentanyl. SETTINGS AND DESIGN Single-centered, prospective single-blind study of sixty patients. MATERIALS AND METHODS Patients between 15 and 45 years of...