There are no conflicts to disclose. Total number of figures: 6 main, 2 supplemental and 1 table Netrin-1 induces medulloblastoma invasion and angiogenesis 3 ABSTRACT Invasion and dissemination of medulloblastoma (MB) within the central nervous system is the principal factor predicting MB treatment failure and death. Netrin-1 is an axon guidance factor implicated in tumor and vascular biology, i...

Certain types ofmacro-CK, type 1, have been reported to cause false increases in CK-MB by co-migration on electrophoresis (1-3). I report two such cases in which the macroCK was an IgA with anti-CK-BB specificity. According to methods proposed by Medeiros et al. (1), immunoprecipitation and subsequent analysis by elecrophoresis was used to separate interfering macre-CK from CK-MB. CK electropho...

The 8th ACESMB workshop took place on September 28, 2015 at the 2015 ACM/IEEE 18th International Conference on Model Driven Engineering Languages and Systems (MoDELS). The workshop brought together researchers and practitioners who work in the area of cyber-physical systems and apply modelbased architecting techniques and tools. The workshop presented novel approaches, both theoretical and prac...

The mechanisms underlying subcellular oxygen transport mediated by myoglobin (Mb) remain unclear. Recent evidence suggests that, in the myocardium, transverse diffusion of Mb is too slow to effectively supply oxygen to meet the immediate mitochondrial oxygen demands at the onset of muscle contractions. The cell may accommodate the demand by maintaining the distribution of Mb to ensure a suffici...

Methylene blue (MB) inhibits the aggregation of tau, a main constituent of neurofibrillary tangles. However, MB's mode of action in vivo is not fully understood. MB treatment reduced the amount of sarkosyl-insoluble tau in Drosophila that express human wild-type tau. MB concurrently ameliorated the climbing deficits of transgenic tau flies to a limited extent and diminished the climbing activit...

A procedure for synthesizing 500-mb. height and temperature data over oceanic areas using only sea level data as an input is developed. The procedure is tested by comparing the synthetic data to observed 500-mb. data at 4YN and 4YP and by comparing 500-mb. synthetic data charts to 500-mb. charts based on observed data. The North Pacific is chosen for the latter test. The 500-mb. height variatio...

Medulloblastoma (MB) is a malignant primary brain tumor with poor prognosis. MB-derived CD133/Nestin double-positive cells (MB-DPs) exhibit cancer stem-like cell (CSC)-like properties that may contribute to chemoradioresistance, tumorigenesis and recurrence. In various tumors, signal transducer and activator of transcription 3 (STAT3) upregulation including MB which can regulate the expression ...

BACKGROUND AND PURPOSE Microbubbles (MB) combined with ultrasound (US) have been shown to lyse clots without tissue-type plasminogen activator (tPA) both in vitro and in vivo. We evaluated sonothrombolysis with 3 types of MB using a rabbit embolic stroke model. METHODS New Zealand White rabbits (n=74) received internal carotid angiographic embolization of single 3-day-old cylindrical clots (0...

Methanobactins (mb) are low-molecular mass, copper-binding molecules secreted by most methanotrophic bacteria. These molecules have been identified for a number of methanotrophs, but only the one produced by Methylosinus trichosporium OB3b (mb-OB3b) has to date been chemically characterized. Here we report the chemical characterization and copper binding properties of a second methanobactin, wh...