OBJECTIVE To investigate the efficacy, potential limitations, and biological mechanisms of UV-A1 phototherapy for skin sclerosis due to collagen deposition disorders. DESIGN Before-and-after trial of UV-A1 irradiation of sclerotic skin; in vivo biochemical analyses after UV-A1 irradiation of normal skin. SETTING Academic referral center. PARTICIPANTS Patients with morphea/scleroderma or s...

In external beam radiation therapy (EBRT), skin dose measurement is important to evaluate dose coverage of superficial target volumes. Treatment planning systems (TPSs) are often inaccurate in this region of the patient, so in vivo measurements are necessary for skin surface dose estimation. In this work, superficial dose distributions were measured using radiochromic translucent poly(vinyl alc...

PURPOSE Cone beam computed tomography (CBCT) is fast becoming standard on modern linear accelerators. CBCT increases the dose to regions within and outside the treatment field, potentially increasing secondary cancer induction and toxicity. This study quantified megavoltage (MV) CBCT skin dose and compared it to skin dose delivered during standard tangential breast radiotherapy. METHOD Dosime...

BACKGROUND EBT and EBT3 radioChromic films have been used in radiotherapy dosimetry for years. OBJECTIVE The aim of the current study is to compare EBT and EBT3 radioChromic films in dosimetry of radiotherapy fields for treatment of parotid cancer. METHODS Calibrations of EBT and EBT3 films were performed with identical setups using a 6 MV photon beam of a Siemens Primus linac. Skin dose wa...

introduction: the complex geometry of breast and also lung and heart inhomogeneities near the planning target volume (ptv) result in perturbations in dose distribution. this problem can result in overdosage or underdosage in the match region of the three treatment fields. the purpose of this study is to create a homogeneous dose distribution in the match region between the supraclavicular and t...

Air pollution has considerable effects on the human skin, showing that every single pollutant a different toxicological impact it. The oxidative stress exceeds skin’s antioxidant capacity can lead to damage and premature skin aging by repeated air contact. In this study, according generalized protocol available objectively substantiate ‘anti-pollution’ claim, we evaluated several biomarkers aft...

BACKGROUND AND PURPOSE As the use of 3D rotational angiography (3D RA) for the evaluation of cerebral vasculature becomes more widespread, it is important to evaluate this imaging method's effect on patient radiation dose. The purpose of the study is to measure 3D RA radiation dose as compared with biplanar digital subtraction angiography (DSA). METHODS The distribution and peak skin dose wer...

Omadacycline, a first-in-class aminomethylcycline antibiotic, is related to tetracyclines but is structurally modified to circumvent mechanisms of resistance to tetracyclines. Omadacycline demonstrates potent activity against a broad range of pathogens, including drug-resistant strains, and is in late-stage development for treatment of acute bacterial skin and skin structure infections and comm...

Our purpose was to determine the effective biological dose and/or maximum tolerated dose of recombinant human tumor necrosis factor receptor:IgG chimera (rhuTNFR:Fc; Immunex, Seattle, WA) in combination with interleukin 2 (IL-2) with regard to reduction in IL-2 toxicity and modulation of biological effects of high-dose IL-2 administration. Twenty-four patients with metastatic cancer were treate...