Despite much interest in the mechanisms regulating fetal-maternal interactions, information on leukocyte populations and major cytokines present in uterus and placenta remains fragmentary. This report presents a detailed and quantitative study of leukocyte populations at the mouse fetal-maternal interface, including a comparison between pregnancies from syngeneic and allogeneic crosses. Our res...

Being able to map accurately placental blood flow in clinics could have major implications in the diagnosis and follow-up of pregnancy complications such as intrauterine growth restriction (IUGR). Moreover, the impact of such an imaging modality for a better diagnosis of placental dysfunction would require to solve the unsolved problem of discriminating the strongly intricated maternal and feta...

Several miRNAs are expressed in human gestational tissue, and some have been shown to be associated with placental dysfunction and complicated pregnancy outcomes. To investigate the roles of miR-346 and miR-582-3p in adverse obstetric events, we analyzed these 2 miRNAs in three samples (maternal blood, umbilical cord blood and placenta) obtained from pregnant women in four groups, including hea...

Fluoride and calcium concentrations in maternal plasma and in placental tissue were determined in 30 healthy women residing in an area with a relatively low water and air fluoride (fluorine) content. The mean fluoride concentrations in maternal plasma and in marginal and central parts o f placenta were 4.27 pMlL, 42.1 pglg of ash, and 33.7 pglg of ash, respectively. The mean calcium concentrati...

Objective(s): The mechanism via which genistein, the major isoflavone content of soya, adversely influenced placenta and fetal development was evaluated in pregnant laboratory rats.Materials and Methods: There were control, 2 mg/kg and 4 mg/kg genistein groups of rats with five sub-groups based on gestation termination day. At the end of...

Extravillous trophoblasts (EVTs) play a central role in educating maternal leukocytes, endometrial stromal and endothelial cells to generate a receptive decidual microenvironment tailored to accept the semi-allogeneic fetus. HLA-G, a non-classical HLA class I molecule endowed with immune-regulatory functions, is primarily expressed on EVTs lining the placenta and on the naturally occurring tole...

Human placenta is rich in mesenchymal stem/stromal cells (MSC), with their origin widely presumed fetal. Cultured placental MSCs are confounded by a high frequency of maternal cell contamination. Our recent systematic review concluded that only a small minority of placental MSC publications report fetal/maternal origin, and failed to discern a specific methodology for isolation of fetal MSC fro...

The placenta forms a selective barrier that functions to transport nutrients that are of critical use to the fetus. Nutrient transport across the placenta is regulated by many different active transporters found on the surface of both maternal and fetal facing membranes of the placenta. The presence of these transporters in the placenta has been implicated in the facilitation of nutrient diffus...

This investigation was undertaken to assess the combined effects of protein restriction and ultrasonic energy exposure during pregnancy on the maternal and fetal mouse. Pregnant female mice were fed diets containing either 18% casein (control diet) or 6% casein (restricted protein diet) during gestation. All animals were subjected to the ultrasonic exposure procedure (actual: 2.5 W/cm2 spatial ...

Dangerous placenta previa refers to somebody has a history of cesarean section while this pregnancy was placenta previa with the placenta attached to the original scar. The placenta can be adhered to the surface of the uterus, invasion into myometrium or completely penetrate the muscle and tissues in these placenta previa patients. It happens in these persons like older maternal ages (over 35 y...