OBJECTIVE Adipose tissue dysfunction, characterized by dysregulation of adipokines production and/or secretion, has been implicated in the pathophysiology of type-2 diabetes mellitus, a metabolic complication closely related to gestational diabetes mellitus (GDM). Recently, an association between circulating maternal visfatin, a novel adipokine with metabolic and immunoregulatory properties, an...

Background: HbA1C has been a known predictor and diagnostic test for diabetes type 2. However, this test has not yet been widely studied in GDM and more importantly no cutoff point has been defined for HbA1C in GDM. We investigated the efficacy of screening during first and second trimester of pregnancy and defined appropriate cutoff points according to HbA1C and FBS for predicting maternal GDM...

conclusions the amount and intensity of physical activity during pregnancy is associated with a lower risk of gestational diabetes mellitus. as a result, the pregnant iranian females have to be encouraged to do regular daily physical activity during pregnancy, if there is no specific contraindication to it. results females who had low total physical activity according to the pregnancy physical ...

Background: External genital anomalies are the most common congenital disorders in male infants with unknown etiology in the majority of cases. According to recent reports, incidence rate of these anomalies is rising in different countries. This study aimed to evaluate the prevalence of external genital anomalies and possible underlying factors in male newborns. Methods: This cross-sectional st...

The aim of this research was to analyze the features morphofunctional state left ventricular contractile cardiomyocytes offspring mothers with experimental type 1 diabetes mellitus during neonatal period. Diabetes modeled in sexually mature female rats using streptozotocin. Specific area myocardial stroma and parenchyma, number cardiomyocytes, nuclear-cytoplasmic ratio, content binucleated cell...

IN BRIEF Restriction of dietary carbohydrate has been the cornerstone for treatment of gestational diabetes mellitus (GDM). However, there is evidence that a balanced liberalization of complex carbohydrate as part of an overall eating plan in GDM meets treatment goals and may mitigate maternal adipose tissue insulin resistance, both of which may promote optimal metabolic outcomes for mother and...

abstract introduction: in recent years, many studies employed and found an association between type 2 diabetes mellitus and colorectal cancer. although increased risk of colorectal cancer in individuals with non insulin dependent diabetes mellitus (niddm) has been observed in previous studies, limited information is available on the colorectal cancer associated with niddm in iran. the purpose o...

G estational diabetes mellitus (GDM), which complicates 3–7% of all pregnancies, is associated with increased maternal and fetal morbidity (1). Identification of early risk markers may result in improved understanding of disease pathogenesis and identification of potential targets for intervention. We sought to determine the association between early pregnancy insulin resistance and subsequent ...

Background: Weight gain during pregnancy is of great concern for most women and obstetricians because its possible consequences. This exists gestational weight that exceeds what recommended by the Institute Medicine associated with many maternal fetal complications. While excessive (GWG) modifiable risk factors Gestational Diabetes Mellitus (GDM) notably, obesity overweight conditions, there a ...

BACKGROUND Oxidative stress is manifested in embryos exposed to maternal diabetes mellitus, yet specific mechanisms for diabetes mellitus-induced heart defects are not defined. Gene deletion of intermediates of Wingless-related integration (Wnt) signaling causes heart defects similar to those observed in embryos from diabetic pregnancies. We tested the hypothesis that diabetes mellitus-induced ...