OBJECTIVE To investigate maternal, perinatal, and neonatal outcomes of pregnancies in women with type 1 diabetes in the Netherlands. DESIGN Nationwide prospective cohort study. SETTING All 118 hospitals in the Netherlands. PARTICIPANTS 323 women with type 1 diabetes who became pregnant between 1 April 1999 and 1 April 2000. MAIN OUTCOME MEASURES Maternal, perinatal, and neonatal outcome...

background: we sought to compare the effectiveness and safety of sublingual versus vaginal misoprostol for the termination of pregnancy with a live full-term fetus. methods: this randomized, triple-blind, placebo-controlled clinical trial was performed on 200 primiparous women with normal, singleton, full-term pregnancies candidated for the induction of labor. sublingual and vaginal tablets con...

The results of a UK randomised controlled trial suggest that metformin taken by nondiabetic obese women during pregnancy has no statistically significant effect on neonatal birthweight or other maternal and neonatal secondary outcomes compared with placebo. Maternal diarrhoea and vomiting were more common with metformin. This study supports NICE guidance on weight management before, during and ...

Drug abuse in pregnancy is not uncommon, and the use of illicit opioids during pregnancy is associated with an increased risk of adverse outcomes. The aim of the study was to assess neonatal outcome of pregnancy with maternal addiction. Materials and Methods:   In this cohort study we assessed 100 pregnant women 15 -49 years old. To identify drug exposure was used self- questionnaire (Self-Repo...

OBJECTIVE The aim of this meta-analysis was to determine the efficacy and safety of glyburide as a treatment for gestational diabetes mellitus (GDM) compared to insulin. METHODS A meta-analysis was conducted to compare the management of gestational diabetes with glyburide and insulin. Studies fulfilling all of the following inclusion criteria were included in this meta-analysis: subjects were...

Background Neonatal mortality comprises a large part of infant mortality, and it depends largely on neonatal birth weight. Besides maternal diseases, it seems that other important factors such as maternal demographic characteristics, mental health and marital satisfaction, affects their infants birth weight. This study conducted aiming to evaluate these affecting factors on neonatal birth weig...

OBJECTIVE To perform a decision analysis to understand better the implications of 19 potential group B streptococcus screening and treatment strategies. METHODS We searched the literature to locate appropriate articles from which to derive probability estimates. Using decision analysis, we determined the likely outcomes of 19 group B streptococcus screening and treatment strategies and focuse...

Background & aim: One of the factors of affecting maternal anxiety is a history of fetal death or neonatal death. This anxiety affects fetal and maternal health. By consideration the impact of anxiety on fetal and maternal health and the lack of protective activities in this field, this study was done to determine the impact of adaptation with pregnancy educational package on anxiety and matern...

maternal vitamin d deficiency is one of the major risk factors for neonatal vitamin d deficiency followed by neonatal hypocalcaemia. the aim of this study is to determine the relationship between delayed neonatal hypocalcaemia and maternal vitamin d deficiency. this is a descriptive cross-sectional study. target population of this study included all term and preterm neonates with delayed hypoca...

objective: to evaluate the safety and efficacy of isosorbide mononitrate (imn) as a cervical ripening agent prior to induction of labour in term pregnant women. materials and methods: a randomized placebo-controlled study was conducted on 100 term singleton pregnancies planned for induction of labour. the participants were randomly assigned to two groups. one group received 40 mg imn and the ot...