Benign mammary lumps and mastalgia are the most common breast disorders; yet, there is no clear-cut consensus about the best strategy for their treatment. We hypothesized that a combination, including boswellic acid, betaine, and myoinositol, would be beneficial in breast disorders by exerting a pleiotropic effect on multiple pathways. Indeed, myoinositol has already been proven to modulate som...

Centchroman (INN: Ormeloxifene), a reversible post-coital/weekly oral contraceptive (half-life of about 168 hours), designed and developed at CDRI, Lucknow is the only non-steroidal oral contraceptive in clinical use in the world today. Synthesized in 1967 and completing pre-clinical and clinical studies in 1989, this drug was approved for marketing in 1991, social marketing in 1995 and NFPW in...

INTRODUCTION Many physiological changes of breast elasticity depend on the age, hormonal status, menstrual cycle and many others. The aim of this study was to evaluate viscoelastic properties of normal breast tissues in a large group of women and to search for factors which play a role in its mechanical properties. MATERIAL AND METHODS 101 women aged 18-74 years who underwent B-mode sonograph...

Percutaneous progesterone topically applied on the breast has been proposed and widely used in the relief of mastalgia and benign breast disease by numerous gynecologists and general practitioners. However, its chronic use has never been evaluated in relation to breast cancer risk. The association between percutaneous progesterone use and the risk of breast cancer was evaluated in a cohort stud...

Objective: To determine frequency of different breast disorders in female patients varying age groups presenting to HBS Hospital Islamabad. Study design: A prospective descriptive study Place and duration: This was conducted department General Surgery from 1st May 2019 31 Dec 2021. Methodology: All surgical OPD indoor 2021 for diseases with no limitation were included the study. Data as at pres...

Objectives: 1) to determine the elasticity of normal breast tissue (parenchyma and premammary adipose tissue) in healthy women using ultrasound two-dimensional shear wave elastography (2D-SWE); 2) reveal a possible correlation between increased stiffness parenchyma hyperprolactinemia patients with mastodynia mastopathy; 3) evaluate ability Vitex agnus-castus drug reduce glandular tissue; 4) obj...