Introduction: It has been reported recently that urine concentrations of cross-linked N-telopeptides of type I collagen (NTX), a marker of bone resorption, may be elevated in total hip replacement patients with radiographic evidence of periprosthetic osteolysis (1). However, it remains unclear whether bone markers possess the sensitivity to detect early, non-radiographic osteolysis. In the pres...

Total joint replacement, although considered an excellent surgical procedure, can be complicated by osteolysis induced by implant particles and subsequent aseptic loosening of the implant. The pathogenesis of implant-associated osteolysis includes inflammatory and osteolytic processes. The sustained chronic inflammatory response initiated by particulate debris at the implant-bone interface is m...

Total joint replacement, although considered an excellent surgical procedure, can be complicated by osteolysis induced by implant particles and subsequent aseptic loosening of the implant. The pathogenesis of implant-associated osteolysis includes inflammatory and osteolytic processes. The sustained chronic inflammatory response initiated by particulate debris at the implant-bone interface is m...

Extensive osteolysis adjacent to orthopedic implants is often associated with wear particles of prosthetic material. The activation of the RANKL/RANK/OPG system is considered to be a likely cause of periprosthetic osteolysis leading to implant failure. The aim of this study was to examine the possible correlation between the clinical extent of osteolysis, the number of wear particles and expres...

For the semester project, we are aiming to develop an intuitive, haptic interface that will allow for improved control over a surgical manipulator designed for application in removal of osteolysis. Current surgical options for osteolysis removal require manual surgery that often leaves much of the lesion unexplored, and, thus, researchers at the Applied Physics Lab and Johns Hopkins University ...

Wear debris causes biological response which can result in periprosthetic osteolysis after total joint replacement surgery. Nuclear factor-kappa B (NFκB), a representative transcription factor involved in inflammation, is believed to play an important role in this event by regulating the production of proinflammatory mediators and osteoclastogenesis. In this study, we sought to determine whethe...

Total hip replacement has consistently been shown to be one of the most reliable and successful surgical procedures in orthopaedic surgery . However time, the longevity of total hip replacement implants may be limited by osteolysis and aseptic loosening regardless of the method of fixation . Osteolysis manifests itself by causing progressive periprosthetic bone resorption secondary to the biolo...

The RANKL-induced NF-κB signaling pathway is required for osteoclast formation and function. By screening for compounds that inhibit RANKL-induced NF-κB activation using a luciferase reporter gene assay in RAW264.7 cells, we identified triptolide (PG490), as a candidate compound targeting osteoclast differentiation and osteoclast-mediated osteolysis. Triptolide (PG490) is an active compound of ...

There are many causes of inflammatory osteolysis, but regardless of etiology and cellular contexts, the osteoclast is the bone-degrading cell. Thus, the impact of inflammatory cytokines on osteoclast formation and function was among the most important discoveries advancing the treatment of focal osteolysis, leading to development of therapeutic agents that either directly block the bone-resorpt...