Mouse double-minute 2 homologue (MDM2) is a key negative regulator of the tumor suppressor p53 that initiates cell cycle arrest and apoptosis upon cellular stresses (Chen et al., 2014; Song et al., 2014). MDM2 directly binds to and inhibits p53 pathway by regulating its location, stability and activity (Michael and Oren, 2003). The mice with reduced MDM2 expression showed increased apoptosis in...

The term ‘nucleosome remodelling’ subsumes a large number of ATPdependent changes of canonical nucleosome structure brought about by dedicated nuclear enzymes, which are usually part of larger, multifactorial complexes (Becker and Hörz, 2002; Havas et al., 2001; Lusser and Kadonaga, 2003; Neely and Workman, 2002). Collectively, nucleosome remodelling machines endow chromatin with dynamic proper...

The Atmospheric Emitted Radiance Interferometer (AERI) measures downwelling infrared radiance from 550-3000 cm (18.2 – 3.3 μm) at high-spectral-resolution (~ 1 cm) (Knuteson et al. 2004). The original temporal sampling strategy (a 3-min average of sky radiance every 8 min) was chosen to optimize the signal-to-noise in the observations for clear sky applications. Clear-sky AERI observations have...

1. introduction current statistical methods may be unable to accurately predict recurrence intervals of rare, large magnitude floods. the usual procedure involves extrapolation from gauged hydrological records documenting 30–40 year records of observed (normally small) floods to the estimation of the quantifies and recurrence intervals of very large, rare floods. this conventional approaches be...

Although conservation of thermodynamics is much less studied than of sequences and structures, thermodynamic details are biophysical features different from but as important as structural features. As a succession of previous research which revealed the important relationships between thermodynamic features and miRNA maturization, this article applies interspecies conservation of miRNA thermody...

A recent study evaluated the effects of compost salinity on the performance of plants often used in herbicide bioassays and demonstrated that salinity and pH of compost test media significantly influenced plant growth, leading in some cases to stunting, yieldreduction and total-loss of seedlings (Brinton, et al. 2005). The principal cause of harmful effects was shown to be salinity with seconda...

Minimally invasive surgery (MIS) is ideally suited to diagnosis and treatment of all forms of diaphragmatic defects. Obviously, the laparoscope affords accurate direct imaging of defects that have classically eluded accurate description by radiological techniques, and does so with minimal morbidity. But laparoscopy also allows repair of these defects with increased precision and vastly decrease...

Introduction Integrins comprise a large family of a/b-heterodimeric receptors that mediate cell adhesion to components of the extracellular matrix. Integrins form transmembrane links with the actin cytoskeleton and activate cytoplasmic signaling cascades to promote cell adhesion, migration, proliferation, survival and differentiation (Gahmberg et al., 2009; Hynes, 2002). By regulating these cel...

background: wilms' tumor is an emberyonal tumor arising from remnants of immature renal tissue. her2/neu is an onco-protein which mediates cellular proliferation, differentiation and survival. methods: in the current study, we analyzed her2/neu expression in 40 wilms' tumors. the clinico-demographic data of 40 patients with wilms' tumor were retrieved. immunohistochemical staining for her2/neu ...

Room temperature ionic liquids (RTILs) are comprised of bulky organic cations and anions (Holbrey & Seddon, 1999; Weingärtner, 2008). Because of the intricate interplay of various interand intramolecular interactions, RTILs have rich dynamical properties and have found diverse applications. In particular, negligible vapor pressure of RTILs makes them a green alternative of conventional organic ...