We treated 13 children with histologically confirmed cystic tuberculosis of bone. Ten had solitary cystic lesions and three had the multicystic form. Signs and symptoms were related mainly to the joint adjacent to the cyst. Most lesions were in the metaphyses of long bones. They were radiolucent, round or oval, and resembled pyogenic infections, aneurysmal and simple bone cysts, cartilaginous t...

We report two infants who presented with inflammatory thigh swelling in first 6 months of life. BCG scar was seen over left upper arm in both. Mantoux test, chest X-ray and family screening were normal in both infants. Ultrasonography confirmed an intramuscular abscess in one child and subcutaneous abscess in the others. Histopathology showed granulomatous inflammation with caseous necrosis sug...

We present the case of a 37 year-old female who had disseminated tuberculosis (TB) with bilateral adrenal involvement resulting in primary adrenal failure (Addison's disease) with refractory hyponatraemia and possible extrapontine 'myelinolysis'. Laboratory results were remarkable for adrenal insufficiency. A Mantoux reaction was positive with evidence of pulmonary miliary TB. The magnetic reso...

Lichen scrofulosorum is a rare form of tuberculid seen in children and young adults. The cutaneous lesions are typically symptomless papular eruptions, associated with a strong Mantoux reaction, tuberculosis of lymph nodes and/or other organs or rarely following BCG vaccination. We describe an unusual case of occurrence of lichen scrofulosorum following BCG immunotherapy in a patient with lepro...

It is well known that after Bacille Calmette-Gue'rin (B.C.G.) vaccination the degree of allergy as shown by the tuberculin test is of a lesser order than that after infection with virulent tubercle bacilli. For this reason it may be necessary to perform several successively stronger tuberculin tests up to 100 units of old tuberculin (Mantoux 1/100) before a positive post-vaccination test is obt...

Tuberculosis (TB) is a major global health problem, ranking as the second highest cause of death from an infectious disease globally, after human immunodeficiency virus (HIV). Nigeria ranked first in Africa with burden TB. public problem about 407,000 people infected. The World Health Organization estimates that 120,000 developed TB 2019, 154,000 whom, 13% were HIV positive individuals. Among i...

Objective: The interleukin-12/interferon-γ (IL-12/IFN-γ) pathway is the most validated cytokine regulating Mycobacterium tuberculosis infection. role of IL-12/IFN-γ axis in protecting against (TB) exhibited people having mutations genes encoding these cytokines. We aimed to study serum levels IL-12 and IFN-γ pediatric their correlation with clinical microbiological features. Material Methods: A...

It is well known that after Bacille Calmette-Gue'rin (B.C.G.) vaccination the degree of allergy as shown by the tuberculin test is of a lesser order than that after infection with virulent tubercle bacilli. For this reason it may be necessary to perform several successively stronger tuberculin tests up to 100 units of old tuberculin (Mantoux 1/100) before a positive post-vaccination test is obt...

OBJECTIVE The purpose of this study was to explore the association between tuberculin reaction size in contacts with positive tuberculin skin test results and a variety of contact and index patient variables. PATIENTS AND METHODS We reviewed the contact investigation records for tuberculosis patients identified by the Tuberculosis Prevention and Control Center of Lleida, Spain, over a period ...