An efficient, simple-to-perform, one-pot reaction cascade to 2-methylenepyrrolidines from p-toluenesulfonyl protected imines and propargylated malonates under a combination of base and copper(I) catalysis is reported.

1 Department of Organic and Pharmaceutical Chemistry, Institute of Tropical Health, Universidad de Navarra, 31008 Pamplona, Spain; [email protected] (R.P.-B.); [email protected] (E.M.-V.); [email protected] (M.S.-V.) 2 Departamento de Parasitología, Instituto de Investigación Biosanitaria (ibs.GRANADA), Hospitales Universitarios de Granada/Universidad de Granada, 18014 Granada, S...

Mannich bases of thymol were synthesized. The aminomethylation reaction was realised in the ortho position of the phenol for compounds 2 (dipropylamine), 3 (benzylamine), and 4 (dibenzylamine) while it was from para position for 1 (dimethylamine), 5 (piperidine), 6 (morpholine) and 7 (N-methylpiperazine). The carbonic anhydrase (CA, EC 4.2.1.1) inhibitory effects of the compounds were asssessed...

A dual catalytic system combining photoredox and Lewis base catalysis has been developed. By the appropriate choice of light source and catalyst, the photoredox cycle can be optimally modulated to match the base catalyzed reaction cycle to provide the corresponding products under mild reaction conditions.

A new series of vanadyl(IV), manganese(II), iron(II), nickel(II) and copper(II) complexes of N-[phenyl(pyrrolidin-1-yl)methyl]benzamide(PBB) have been synthesized and characterized by elemental analysis, molar conductance, IR, electronic, EPR spectra and magnetic measurements. Conductance measurements indicate that the above complexes are non-electrolytes. The spectral data show that, the ligan...

In the title Mannich base, C(20)H(21)N(3)O(3), an isatin derivative of thymol, the O-CH(2)-C(=O)-N(H)-N fragment connect-ing the aromatic and fused-ring systems is approximately planar, with the N-N single bond in a Z configuration. The amino H atom of this N-N fragment is intra-molecularly hydrogen bonded to the carbonyl O atom of the indolinone fused ring as well as to the phen-oxy O atom of ...

The title compound, C(23)H(30)N(2)O(4), is a Mannich base useful for studying the effect of an electron-donating phenol substituent on intra-molecular hydrogen bonding. In the mol-ecular structure, the cyclo-hexane ring adopts a chair conformation and the five-membered ring has a twisted envelope conformation. Each meth-oxy group is oriented in the same plane of the respective aromatic ring, sh...

Two new Schiff and Mannich bases, namely, 1-Morpholinomethyl-3(1' -N-dithiooxamide)iminoisatin (L(I)H) and 1-diphenylaminomethyl-3-1'-N-dithiooxamide)iminoisatin (L(II)H), were prepared from condensation reaction of new Schiff base 3-(1'-N-dithiooxamide)iminoisatin (SBH) with morpholine or diphenylamine respectively in presence of formaldehyde . The structures were characterized by IR, (1)HNMR,...