Extranodal non-Hodgkin's lymphomas constitute 20-25% of overall non-Hodgkin's lymphomas cases and can be managed with very different therapeutic strategies. Therefore, the Italian Society of Hematology and the two affiliate societies (the Italian Society of Experimental Hematology and the Italian Group of Bone Marrow Transplantation) appointed a panel of experts to produce clinical practice-gui...

Gastric marginal zone B-cell lymphoma of MALT type (MALT lymphoma) arises in the context of chronic inflammation induced by the bacterial pathogen Helicobacter pylori. Although generally considered an indolent disease, MALT lymphoma may transform to gastric diffuse large B-cell lymphoma (gDLBCL) through mechanisms that remain poorly understood. By comparing microRNA expression profiles of gastr...

A 75-year-old female, who had an abnormal stomach x-ray finding, was admitted to the hospital for further examination and therapy. Upper GI endoscopy showed reddish and swollen folds on the greater curvature of the gastric body and a biopsy was of this lesion revealed malignant lymphoma (small cell type or mucosa-associated lymphoid tissue (MALT) lymphoma suspected). The patient was infected wi...

Aim: Vascular endothelial growth factor (VEGF) and VEGF receptor are over-expressed in lymphomagenesis. The aim of this study was to evaluate the usefulness of 123 I-VEGF165 scintigraphy for imaging of B-cell lymphoma of the Mucosa-Associated Lymphoid Tissue MALT lymphoma). Methods: Three Patients (age range: 52-71 years) with histopathological verified MALT lymphoma were included in the study....

Non-Hodgkin lymphoma (NHL) may occur among hepatitis C virus (HCV)-infected individuals. HCV is one of the most common blood-borne pathogens transmitted from patients to health-care workers (HCWs). The development of NHL among HCV-infected HCWs has recently been shown. To investigate this issue further a tailored health surveillance program was applied to 3,138 HCWs from four Medical Institutio...

Introduction: MALT (mucosa associated lymphoid tissue) lymphomas comprise a heterogeneous group, originally thought to be derived from the marginal zone B­cells that are found surrounding B­cell follicles and within the adjacent lymphoepithelium. They arise most commonly in extranodal organs such as the stomach, major salivary glands and thyroid. Thus, they can be precisely described as extrano...

Mucosa-associated lymphoid tissue (MALT) lymphoma has drawn attention in the last twenty years due to its pathological and clinical characteristics. It is a question of B-cell neoplasm with extranodal origin, and with invariable prolonged localisation, indicating indolent malignancy. It is believed that this type of lymphoproliferative neoplasm is triggered by chronic antigenic stimulation. Thi...

Gastrointestinal lymphoma is the most common form of extranodal lymphoma, accounting for 30%-40% of cases. The most commonly involved site is the stomach (60%-75% of cases), followed by the small bowel, ileum, cecum, colon and rectum. The most common histological subtypes are diffuse large B-cell lymphoma (DLBCL) and marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT)....