Growth hormone (GH) is essential for quality of life in both children and adults, but it is also believed to enhance the growth of various neoplasms. However, the role of GH in the brain, particularly in brain tumors, has yet to be established. To clarify these problems from the perspective of receptor expression, we examined GH receptor (GHR) expression in brain tumors using immunohistochemist...

Introduction: Ovarian tumors have various histomorphological patterns. Histopathological examination plays an important role is classifying ovarian tumors for better prognosis. Ovarian tumors are classified into surface epithelial tumors, germ tumors and sex cord stromal tumors. This study was done to know various histomorphological patterns of ovarian tumors. Materials and Methods: Both retros...

BACKGROUND The aim of this study was to identify a biomarker useful in the diagnosis and therapy of ovarian malignant germ cell tumor (OMGCT). METHODS The karyopherin 2 (KPNA2) expression in OMGCT and normal ovarian tissue was determined by standard gene microarray assays, and further validated by a quantitative RT-PCR and immunohistochemistry. The correlation between KPNA2 expression in OMGC...

Ovarian neoplasms have become increasingly important not only because of the large variety of neoplastic entities but more because they have gradually increased the mortality rate due to female genital cancers. A total of 120 cases of ovarian tumors were studied at the Department of Pathology, Konaseema Institute of Medical Sciences, Amalapuram, India, during the period of March 2005 to March 2...

1Department of Urology, Gulf Medical College Hospital & Research Center, 2Dept. of Pathology, Gulf Medical University, Ajman, UAE. Correspondence: Dr. Ihsan Ullah Khan, Department of Urology, Gulf Medical College Hospital & Research Center, Ajman, UAE. email: [email protected] INTRODUCTION Testicular tumors are rare in children, but highly treatable and usually curable. In children testicular...

OBJECTIVE To identify the different histopathological types of ovarian neoplasms and their age distribution. METHODS This is a retrospective study were ovarian neoplasms received by the Pathology Department of King Abdulaziz University, Jeddah, Saudi Arabia between January 1995 and December 2010 were reviewed and their frequencies in different age groups were calculated. RESULTS Out of 618...

BACKGROUND Amplification and/or overexpression of HER-2/neu are associated with poor clinical outcome in several epithelial tumors. However, the exact prognostic role of HER-2/neu expression in testicular germ-cell tumors is equivocal. PATIENTS AND METHODS Since teratomas are relatively chemoresistant tumors, we evaluated the HER-2/neu alterations of 59 primary testicular teratomas and mixed ...

BACKGROUND Diffusion-weighted imaging (DWI) is a noninvasive method for investigation of tumor histological content. It has been applied for some musculoskeletal tumors and reported to be useful. OBJECTIVES The aim of the present study was to prospectively evaluate the apparent diffusion coefficient (ADC) values of benign and malignant soft tissue tumors and to determine if ADC can help diffe...