Background: P53 tumor suppressor gene mutation is one of the most common genetic alterations in human malignancies. The mutated from of the gene is stable and can be detected with immunohistochemistry methods. There is much controversy about the expression rate of this gene in malignant melanoma. Objective: To determine the frequency of the P53 antigen expression by sex, age, type and thickness...

Melanoma of the conjunctiva is a rare tumor with incidence from 0,03 to 0,08 cases per 100000 white population. Metastatic malignant melanoma represents approximately 5% of all secondary malignant lung tumors. We report the unexpected discovery of a pulmonary and pleural metastasis from a conjunctival melanoma in a young subject.

We report a case of malignant melanoma of the kidney presenting as a primary tumor. This tumor was found incidentally in a 67-year-old man. This is a rare primer malign melanoma case of the kidney in 67-year old man, with no history of melanoma, presenting with an asymptomatic solitary renal mass. The patient underwent a right radical nephrectomy, We discuss the probability that this tumor is r...

Amelanotic melanoma is a variant of malignant melanoma comprising 2% to 8% of all malignant melanomas. The amelanotic presentation of melanoma in the oral cavity is extremely rare and has been reported only occasionally in the literature. Moreover, the lack of melanin makes these tumors difficult to diagnose than that of pigmented lesions and the prognosis tends to be poorer. Herein, we report ...

OBJECTIVE To investigate the sensitivity of echography vs magnetic resonance imaging (MRI) or computed tomography (CT) for detecting extraocular extension of choroidal malignant melanoma. DESIGN AND SETTING Retrospective review at a university referral center. PARTICIPANTS All patients with histopathologically proven extraocular extension of choroidal malignant melanoma evaluated at the Bas...

Although a rare condition, rosette formation in malignant melanoma has been previously documented. The present study describes the second documented case of malignant melanoma with perivascular pseudorosettes. A 38-year-old male presented with a black nodule on his back. Histopathological study revealed diffuse proliferation of neoplastic cells in the dermis and subcutis. A section of the tumor...

INTRODUCTION Primary malignant melanoma of the esophagus is a rare but highly aggressive tumor with poor prognosis. Surgical resection is the treatment of choice. However, some cases may be diagnosed with advanced inoperable disease. Palliative radiotherapy may be used to relieve symptoms caused by the esophageal tumor. CASE PRESENTATION We report on a case of advanced inoperable primary mali...

Primary gastric malignant melanoma is a rare malignant tumor. The purpose of this study is to determine the origination of primary gastric malignant melanoma. We report a case of a 63-year-old male with a history of right limb movement disorder for one month. The patient underwent microscopic supratentorial mass resection and proximal stomach resection. Hematoxylin-eosin and immunohistochemical...

INTRODUCTION Primary malignant melanoma arising from the anorectum is uncommon. The natural history of anorectal malignant melanoma is that of a very poor prognosis with early dissemination of disease. Successful surgical treatment has been rare. The present series reviews the clinical features and results of surgical management of patients with anorectal malignant melanoma treated in the Depar...

Metastatic lesions in the breast from malignant diseases originated in other primary sources are rare. Mostly arise from the contra-lateral breast. The incidence extramammary origin of the breast metastasis is 1.2-2%. The usual extra-mammary primary sites of metastasis are malignant melanoma, lung cancer and Non-Hodgkin lymphoma. In any patient who has been diagnosed with a known primary cancer...