In the recent years, immune checkpoint inhibitors (ICPI) have been widely used for treatment of many malignant neoplasms. Russian Federation, several ICPIs approved and actively used, namely anti-CTLA-4 monoclonal antibody (ipilimumab), anti-PD-1 antibodies (nivolumab, pembrolizumab, prolgolimab), anti-PD-L1 (atezolizumab, durvalumab). may cause various endocrine immune-mediated adverse events,...

156 iranian patients with primary malignant tumors of the small intestine were reviewed. malignant lymphoma was the most common tumor type, comprising 128 patients (82%), followed by adenocarcinoma (22 patients, 14.1 %), leiomyosarcoma (4 patients, 2.56%) and carcinoid tumor (2 patients, 1.28%). lymphomas and adenocarcinomas were primarily located in the duodenum or jejunum, whereas leiomyosarc...

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malignant neoplasms (MNP). The frequency of PNS in MNP ranges from 1 to 20 % according different authors. One the manifestations is acne, which occurs against background neoplasm due hormonal disorders. presented article describes a clinical case patient with mixed germ cell tumor and metastases retroperitoneal lymph nodes. produced human beta-chorionic gonadotropin, led development acne as PNS...

background:   although the majority of soft tissue masses are benign, it is important to consider malignancy in differential diagnoses. because most soft tissue sarcomas present as a painless mass, clinicians must watch for signs suggestive of malignancy, including large size, rapid growth, and site deep into the deep fascia.the purpose of this study was to determine the relative prevalence acc...

Oral lichen planus (OLP) is a chronic relapsing inflammatory disease. It involves T-lymphocyte aggression targeted to the basal layer of oral mucosa.p53 plays central role in prevention normal cells from development malignant phenotype. Somatic alterations p53 cause defects function. Wild type an important repairable damage cell due cellular stresses. Over-expression, as well polymorphic varian...

BACKGROUND The word "Cancer" itself is sufficient to cause a fear in the minds of people. Early detection of oral potentially malignant and malignant disorders is still a diagnostic challenge for most of the clinicians. In the present study, we have evaluated the efficacy of Rose Bengal staining in the detection of oral premalignant and malignant lesions. AIM The aim of the study was to evalu...

There are few disease entities so confusing as those related to the histiomonocytic cells and their malignant proliferations, defined either as Malignant Histiocytosis or histiocytic lymphoma. Both terms have been considered synonymous and employed indifferently by most Authors, although certain differences in the clinical manifestations have sometimes been outlined. The term “malignant-histioc...

Background: Bone marrow is the site of many malignant disorders and it is one of the common places for solid tumors to metastasize. Examination of the bone marrow aspirate and biopsy is a routine procedure performed for assessment of various conditions such as cytopenias, hematologic neoplasms, nonmalignant disorders and metastatic neoplasms. Methods: The patients were referred to the Hema...