Obesity is increasing at an alarming rate globally. Several studies have shown that premenopausal women have a reduced risk of CV disease and a reduced myocardial susceptibility to ischemia/reperfusion injury. The effect of obesity on myocardial tolerance to ischemia in women has not been established. To determine how obesity affects myocardial susceptibility to ischemia/reperfusion injury in b...

Background: Antioxidants such as α-tocopherol (vitamin E) and β-carotene (vitamin A) play an important role in protective effect of repeated brief periods of ischemia, namely ischemic preconditioning (IPC). Values of these antioxidants were investigated and compared after induction of ischemia reperfusion (IR) and kidney IPC in both male and female rats. Methods: Forty eight Wistar rats were di...

The vascular beds of the upper or lower body of rats were perfused through the aorta with oxygenated Krebs-Ringer solution containing dextran (7 g/100 ml), at 37 degrees C. Perfusion was stopped every 10 minutes, and the pressure rise in the jugular or the femoral vein was recorded during rapid infusion (15.3-90.0 ml/min) of Krebs-Ringer solution into the inferior vena cava. The following group...

Background: Diabetes mellitus is a chronic metabolic disorder that develops due to insulin deficiency or resistance. Recent animal and human studies have reported bromocriptine be effective in the management of type 2 diabetes mellitus. The present study was done evaluate antihyperglycemic effect dexamethasone induced hyperglycemic rats.Methods: Male wistar rats were used divided into 5 groups....

BACKGROUND Accumulating epidemiological evidence shows that life event stressors are major vulnerability factors for psychiatric diseases such as major depression. It is also well known that the resident intruder paradigm (RIP) results in aggressive behavior in male rats. However, it is not known how resident intruder paradigm-induced aggression affects depressive-like behavior in isolated male...

Studies on white outbred 3,54-month-old male rats showed that stress caused by chronic 2-month social isolation has a negative impact reproductive function. A effect of long-term the sexual behavior was revealed: statistically significant increase in latent period until first emotional approach to female, decrease total time approaches, anogenital sniffing female partner, and number allogroomin...

objective(s):this study was designed to investigate the effect of phaleria macrocarpa aqueous extract (pm) on spermatogenesis by observing the histological changes of testes in adult male rats. materials and methods: pm was prepared by boiling the dried slices of p. macrocarpa fruits followed by filtering, centrifugation and freeze-drying to obtain the powder form. eighteen sprague dawley adult...

  Since the stress influences the biological processes, in the present study the effect of prenatal immobilization stress on the sexual activity of male rats was studied. Adult male and female Wistar rats (Pasteur Institute, Tehran) were copulated. After observing the vaginal plugs, pregnant rats were divided into control and two experimental groups. All groups were kept under the laboratory co...

Michler's ketone, a dye intermediate and derivative of dimethylaniline, was selected for bioassay by the National Cancer Institute because of the elevated incidence of bladder cancer noted among dye manufacturing industry workers. A bioassay for the possible carcinogenicity of technical-grade Michler's ketone was conducted using Fischer 344 rats and B6C3F1 mice. Michler's ketone was administere...