The purpose of this ASRM Practice Committee report is to provide clinicians with principles and strategies for the evaluation of couples with male infertility problems. This revised document replaces the document of the same name, last published in 2012 (Fertil Steril 2012;98:294-301).

In the present study, we report on the case of a 43-year-old male patient seeking for fertility assistance, who showed a seminal analysis and testicular biopsy of complete azoospermia. Peripheral blood culture for chromosome studies revealed a karyotype of 46 chromosomes with a ring-Y-chromosome that lost the long arm heterochromatin. Molecular analysis of genomic DNA from the patient detected ...

background: while multiple factors can contribute to male infertility, genetic factors, such as chromosomal disorders or y-chromosome microdeletion, are responsible for about 10% of male infertility. considering the role of y-chromosome microdeletions in men with oligozoospermia who volunteer for in vitro fertilization (ivf), the prevalence of such microdeletions in each particular community ne...

background: sperm dna damage is an important factor in the etiology of male infertility. objective: the aim of the study was to evaluate the association of oxidative stress induced sperm dna damage with the pathogenesis of male infertility. materials and methods: the study comprised a total of 66 subjects, including fertile men (n=25) and infertile men (n=41) matched by age. seminal malondialde...

generated in response to oxidative stress – play an important role in cell protection by performing functions like catalyzing the conjugation of a large variety of endogenous and exogenous compounds including ROS, carcinogenic compounds, and their metabolites. A previous study clearly demonstrated an abundance of GSTs in the male reproductive tract and showed that GSTs play important roles in t...

Chromosomal rearrangements are usually associated with male factor infertility. We report here a 34-year-old man suffering from primary infertility for 15 years. The cytogenetic analysis and investigation of Y-chromosome microdeletions were performed. A reciprocal balanced translocation t (10;19) (q11.2;q13.4) was found in oligozoospermic infertile men with no Y-chromosome microdeletions. In th...

Male infertility is directly or indirectly responsible for 60% of cases involving reproductive-age couples with fertility-related issues. Nevertheless, the evaluation of male infertility is often underestimated or postponed. A coordinated evaluation of the infertile male using standardized procedures improves both diagnostic precision and the results of subsequent management in terms of effecti...

The value of testicular biopsy in male infertility has recently been emphasized by Meinhard, McRae and Chisholm (1973), and the present authors agree with them that a biopsy is essential for the following reasons: (1) to establish a firm diagnosis; (2) to rationalize therapy on the basis of histological findings; (3) new developments in drug therapy and electronmicroscopic techniques will help ...

In male mice heterozygous for a null apolipoprotein B (apoB), allele infertility was noticed. These data led us to investigate a possible role of APOB gene polymorphism and male infertility in humans. In this case-control study, we searched for an association between the insertion/deletion (I/D) polymorphism of the APOB gene and male infertility in 560 Slovene Caucasian men. The study group con...