Abstract The objective of this study was to use matrix-assisted laser desorption ionisation–time flight mass spectrometry (MALDI-TOF MS) for the identification ovine-associated staphylococci. Presumptive Staphylococcus isolates were recovered from ovine udder surface (US), individual raw milk, bulk tank and cheese samples characterised by conventional phenotypic methods. A total 69 bacterial fu...

Quantitative analysis of administered drugs in biological tissues is essential for understanding the mechanisms underlying their e cacy or toxicity. Imaging mass spectrometry (IMS) may allow the quanti cation of targeted drugs in tissue sections along with the visualization of their spatial distribution. In this study, surrogate tissue-based calibration standards were prepared to quantify a sma...

1.1 Motivation Since its inception in the mid-1980’s, matrix assisted laser desorption/ionization (MALDI) has revolutionized analytical and biological chemistry by making possible the detection of large, intact biological molecules in the gas phase. This technique also motivated improvements in mass spectrometry, resulting in significant improvements in resolution and mass accuracy for biologic...

A combinatorial extraction method and an automated matrix-assisted laser desorption/ionization (MALDI) mass spectrometry procedure were used to improve the clinical analysis of the immunosuppressant drug cyclosporin A. Cyclosporin extracts from whole blood were analyzed by MALDI and electrospray ionization (ESI) mass spectrometry, allowing for their identification and quantification. Due to lim...